BiPAP呼吸机联合药物治疗慢性阻塞性肺病急性期的效果

Effect of BiPAP ventilator combined with drug in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的探讨BiPAP无创呼吸机联合药物治疗慢性阻塞性肺病急性期(AECOPD)疗效及对E-选择素、D-二聚体水平的影响。方法选取2013年9月~2017年2月因AECOPD在我院就诊的82例患者纳入研究并随机分组,对照组40例患者采用常规药物治疗,观察组42例采用药物联合BiPAP无创呼吸机治疗,7 d为1个疗程。比较两组患者的临床疗效。结果治疗后,两组患者FEV1/FVC、血氧分压均升高,二氧化碳分压、D-二聚体及E-选择素水平则降低,观察组改善更显著,差异有统计学意义(P<0.05);对照组治疗总有效率为75.00%(30/40),观察组为95.24%(40/42),差异有统计学意义(P<0.05)。结论 BiPAP无创呼吸机联合药物治疗AECOPD的效果显著,可更好地改善患者血气指标及炎症反应,值得推广。

Objective To investigate the effect of BiPAP ventilator combined with drug on acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and its influence on E-selectin and D-dimer.Methods From September 2013 to February 2017,82 COPD patients in acute exacerbation visited our hospital were enrolled and randomly divided into two groups.ln control group （n=40）,conventional medicine was used,while in the observation group （n=42）,noninvasive BiPAP ventilator was added.A course of treatment was lasted for 7 days.The difference of clinical efficacy between the two groups was compared.Results After treatment,the FEVj/FVC and blood oxygen partial pressure were both in- creased,while the level of PaCO2,D-dimer, and E-selectin were decreased.The changes in the observation group were more remarkable,the difference was statistically significant （P〈0.05）.The total effectiveness rate in the control group was 75.00% （30/40）,and 95.24% （40/42） in the observation group,which was higher in the latter,the difference was statistical- ly significant （P〈0.05）.Conclusion Combination of BiPAP and medicine in the treatment of AECOPD obtain a remarkable effect,and can improve the blood gas index and inflammatory reaction,which is worthy of promotion.