曲美他嗪联合阿托伐他汀治疗冠心病同时降低血脂的效果研究

Effect of Trimetazidine combined with Atorvastatin on coronary heart disease and lower blood lipid

目的探索曲美他嗪(TMZ)联合阿托伐他汀在治疗冠心病同时降低血脂的效果。方法选取2015年9月~2016年10月在我院就诊同时患有高血脂与冠心病的73例患者作为研究对象,采用随机分组的方法分为观察组和对照组,观察组37例,对照组36例。对照组采用常规治疗的基础上给予口服TMZ,观察组在采用同样口服TMZ的基础上,再口服阿托伐他汀,治疗两个疗程。比较治疗后两组患者冠心病中的临床效果及不良反应情况,并统计比较治疗前后两组患者在相关血脂指标水平指标及血肌酐、尿素氮及24 h尿蛋白的含量。结果治疗后,观察组患者冠心病临床治疗总有效率高于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者的各血脂指标水平均低于对照组,差异有统计学意义(P<0.05);两组患者的血肌酐和尿氮素指标水平比较,差异无统计学意义(P>0.05);观察组患者治疗后24 h尿蛋白水平低于对照组,差异有统计学意义(P<0.05)。结论与单独服用TMZ比较,利用TMZ联合阿托伐他汀治疗冠心病具有更好的临床效果,降低血脂也更好,建议临床推广使用。

Objective To explore the effect of Trimetazidine（TMZ） combined with Atorvastatin in the treatment of coro- nary heart disease and lower blood lipids.Methods From September 2015 to October 2016,a total of 73 patients with hyperlipidemia and coronary heart disease who were treated in our hospital were selected and divided into observation group and control group by random grouping.The observation group were consisted of 37 patients and the control group of 36 cases.The control group was given oral TMZ on the basis of conventional therapy for two courses.The observation group was treated with oral TMZ combined with Atorvastatinfor two courses.After treatment,the clinical outcomes and adverse reactions were compared, meanwhile,the results of relevant indicators of serum lipid levels and serum creatinine, urea nitrogen and 24 h urine protein of two groups of patients before and after treatment were compared.Results After treatment, the total effective rate of clinical treatment of coronary heart disease in the observation group was higher than that in the control group,the incidence of adverse reactions was lower than that of the control group,the difference was statistically significant （P〈0.05）;after treatment,the observation group of patients with lipid levels were lower than the control group,the difference was statistically significant（P〈0.05）.Serum creatinine and urine nitrogen levels of two groups were compared,the difference was not statistically significant（P〉0.05）,the level of 24 h urinary protein in the observation group was lower than that in the control group,the difference was statistically significant（P〈0.05）.Conclusion Compared with control group,observation group has a better clinical effect,the use of TMZ combined with Atorvastatin can lower blood lipids and get better results,it is recommended to promote the use of clinical.