阿奇霉素联合多索茶碱治疗喘息性支气管肺炎患儿的临床疗效

Clinical Effect of Ambroxol Hydrochloride Combined with doxofylline on Bronchial Pneumonia in Children

目的:探究阿奇霉素联合多索茶碱治疗喘息性支气管肺炎患儿的临床疗效。方法:选取我院2012年1月2015年3月收治的喘息性支气管肺炎患儿87例,对照组48例患儿给予常规治疗,观察组39患儿在对照组基础上给予阿奇霉素联合多索茶碱治疗,两组患儿均治疗7 d比较两组患儿临床疗效,气促缓解,咳嗽消失和肺部哮鸣音消失时间,以及治疗前后白细胞WBC,血清C反应蛋白CRP,免疫球蛋白IgE和嗜酸粒细胞阳离子蛋白ECP水平,以及两组患儿不良反应的情况。结果:观察组和对照组患儿的临床总有效率分别为94.8%,79.2%,两组间比较有统计学差别(P<0.05)。观察组患儿气促缓解,咳嗽消失和肺部哮鸣音消失时间明显短于对照组,差异有统计学意义(P<0.05),观察组治疗后白细胞WBC,血清C反应蛋白CRP,免疫球蛋白IgE和嗜酸粒细胞阳离子蛋白ECP水平明显高于对照组,差异有统计学意义(P<0.05),对照组不良反应发生率为2.1%,与观察组不良反应发生率5.1%比较,差异无统计学意义(P>0.05)。结论:阿奇霉素联合多索茶碱治疗喘息性支气管肺炎患儿的临床疗效确切,能够快速起效,值得临床推广。

Objective： To investigate the clinical Effect of Ambroxol Hydrochloride Combined with doxofylline on Bronchial Pneumonia in Children. Method：A total of 87 children with bronchial pneumonia were selected from January 2012 to March 2015, and they were divided into control group and observation group,48 cases in control group were given conventional treatment, while 39 cases of observation group were given extra Ambroxol Hydrochloride Combined with doxofylline, both groups treated for 7 days. Clinical effect, time of shortness of breath, coughing and lung wheezing sound disappear, WBC, serum CRP, IgE, ECP level before and after treatment were compared. And the incidences of adverse reactions were compared between the two groups. Results：The clinical effect of observation group （94.8%） was statistically significantly better than that of control group （79.2%）. The time of shortness of breath, coughing and lung wheezing sound disappear in observation group was significantly shorter than that in control group （P〈0.05） ; The WBC, serum CRP, IgE, ECP level after treatment were higher than that in control group（P〈0.05）. The incidence of adverse reactions of control group was 2.1%, that of observation group was 5.1%, the difference was not statistically significant （ P〉 0.05 ）. Conclusion： Ambroxol hydrochloride combined with doxofylline certain clinical effect in treating bronchial pneumonia in children, which can work quickly and worthy to be popular.