安定抗麻醉大鼠缺血性心律失常的作用

The Inhibitory Effect of Diazepam on Ischemic Arrhythmia in Anesthetized Rats

目的 :观察安定对麻醉大鼠缺血性心律失常的作用。方法 :给麻醉大鼠注射安定 ,然后结扎冠状动脉左前降支 ,造成心肌缺血 ,观察心律失常发生情况。结果 :安定可明显降低麻醉大鼠的室性期外收缩的数目 ,与对照组相比 ,室性期外发生率大剂量、中级量和小剂量给药组分别降低 96%、90 %和 83 %。室颤发生率对照组 89% ,各给药组分别降低至 0。对室速时程也有明显缩短作用 ,与对照组比 ,大剂量、中级量和小剂量给药组室速时程分别降低 91%、71%和63 %。结论

Objective: To study the inhibitory effect of diazepam on ischemic arrhythmia in anesthetized rats. Methods: An arrhythmia was induced by ligation of Coronary artery in anesthetized rats. Results:Diazepam of 1.25mg/kg, 0.31mg/kg, 0.15mg/kg (iv) can remarkably decrease the number of extra systole, incidence rate of ventricular fibrillation and shorten duration of ventricular tachycardia. Conclusion: Diazepam can produce a marked effect on inhibiting ischemic arrhythmia induced by ligation of coronary in rats.