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基因多态性与支气管哮喘 被引量：1

Gene Polymorphism and Bronchial Asthma
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摘要 支气管哮喘(bronchial asthma),是一种由多种免疫细胞和细胞因子参与的慢性肺部疾病,以可逆性气道阻塞、气道高反应性和气道炎症为特征,并且具有一定的遗传倾向性。研究显示基因多态性在哮喘发病过程中起重要作用,对哮喘基因多态性的研究有助于对分子病理生理学的了解和治疗靶位的探讨,本文就几种哮喘易感性基因的多态性做一综述。 Bronchial asthema is a chronic pulmonary disease participated by many sorts of immunocytes and cytokines,characterized by reversibility airway obstruction,airway hyperreactivity and airway inflammation,additionally,it has certain genetic predisposition.Recent studies suggest that gene polymorphism plays a significance role in the cause of bronchial asthma.The research of gene polymorphism in bronchial asthma is useful to understand the molecular pathophysiology of bronchial asthema and explore the therapeutic targets.The article reviews susceptibility gene of asthma.
作者 王秋义
机构地区 天津医院ICU
出处 《黑龙江医学》 2017年第11期1040-1042,共3页 Heilongjiang Medical Journal
关键词 支气管哮喘 基因 多态性 儿童 Bronchial asthema Gene Polymorphism Children
分类号 R562.25 [医药卫生—呼吸系统]
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  • 1Amoli M,Ollier W E R,Hajeer A H.A novel PCR-RFLP assay for the detection of a polymorphism in the 3′of STAT6 gene[J].Genes Immun,2000,1(5):349-350.
  • 2Gao P S,Mao X Q,Roberts M H,et al.Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma[J].J Med Genet,2000,37(5):380-382.
  • 3Xia B,Crusius J B,W u J,et al.Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease[J].Clin Exp Immunol,2003,131(3):446-450.
  • 4Gabriele Duetsch,Thomas lllig,Sabine Loesgen,et al.STAT6 as an asthma candidate gene:polymorphism-screening,association and haplotype analysis in a Caucasian sib-pair study[J].Human Molecular Genetics,2002,6(11):613-621.
  • 5Karrogawa Y,Lee H J,Johnston J A,et al.Cutting edge:a conditionally active form of STAT6 can mimic certain effects of IL-4[J].J Immunol,1998,161(3):1074-1077.
  • 6Kazushi T,Michiko S,Hirokazu A,et al.Linkage and association studies of STAT6 gene polymorphisms and allergic disease[J].Int Arch Allergy Immunol,2003,131(14):33-38.
  • 7Shimoda K,van Deursen J,Sangster MY,et al.Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene[J].Nature,1996,380(6575):630-633.
  • 8Jacob C O,Lee S K,Strassmann G.Mutational analysis of TNF-alpha gene reveals a regulatory role for the 3′-untranslated region in the genetic predisposition to lupus-like autoimmune disease[J].J Immunol,1996,156(5):3043-3050.
  • 9Bijianzadeh M,Ramachandra NB,Maheah PA,et al.Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population.Lung,2010,18; 415-422.
  • 10Howard TD,Postma DS,Jongepier H,Moore WC,Koppelman GH,ZhengSL,Xu J,Bleecker ER,Meyers DA:Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations.J Allergy Clin Immunol 2003,112(4):717-722.

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黑龙江医学
2017年 第11期

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