HPV感染对宫颈炎患者阴道微生态的影响

Effect of HPV infection on vaginal microecosystem in patients with cervicitis

目的:研究人乳头瘤病毒(HPV)感染对宫颈炎患者阴道微生态的影响。方法:回顾性分析我院2013年11月至2015年11月94例宫颈炎患者临床资料,根据患者HPV感染情况分为HPV阳性组41例,HPV阴性组54例,再选取同时期在我院接受体检的50例健康人临床资料,并设置为对照组,比较三组阴道微生态环境变化情况。结果:HPV阳性组患者阴道乳酸杆菌异常率87.80%较HPV阴性组44.44%及对照组2%显著较高(P<0.05);HPV阳性组菌群密度Ⅱ~Ⅲ级、菌群多样性Ⅱ~Ⅲ级、pH值≤4.5的概率较HPV阴性组和对照组显著较低(P<0.05);HPV阳性组微生态失调率较HPV阴性组和对照组显著较高(P<0.05);HPV阳性组惰性乳酸杆菌、卷曲乳酸杆菌、加氏乳酸杆菌、詹氏乳酸杆菌分布率较HPV阴性组和对照组均显著较低(P<0.05)。结论:HPV感染的宫颈炎患者阴道微生态失调,阴道乳酸杆菌水平显著降低,HPV感染会造成阴道病原体繁殖,增加女性生殖道感染和宫颈上皮细胞异常增生的风险。

Objectives： To study the effect of human papillomavirus（ HPV） infection on vaginal microecosystem in patients with cervicitis. Methods： The clinical data of 94 patients with cervicitis who were admitted to our hospital between November 2013 and November 2015 were retrospectively analyzed. According to the status of HPV infection,the patients were divided into HPV positive group（ n = 41） and HPV negative group（ n = 54）. The clinical data of another 50 healthy persons at the same time were selected as control group. The changes of vaginal microecological environment were compared among the three groups. Results： The abnormal rate of vaginal lactobacilli in HPV positive group（ 87. 80%） was significantly higher than that in HPV negative group（ 4. 44%） and control group（ 2%）（ P〈0. 05）. The probabilities of grade Ⅱ ~ Ⅲ bacteria density,grade Ⅱ ~ Ⅲ bacterial diversityand PH ≤ 4. 5 in HPV positive group were significantly lower than those in HPV negative group and control group（ P〈0. 05）. The rate of microdysbiosis in HPV positive group was significantly higher than that in HPV negative group and control group（ P〈0. 05）. The distribution rates of inert lactobacillus,Lactobacillus crispatus,Gardner lactobacillus and Lactobacillus acidipropionici in HPV positive group were significantly lower than those in HPV negative group and control group（ P〈0. 05）. Conclusion： HPV infected patients with cervicitis have vaginal microdysbiosis and the vaginal lactobacilli level increases significantly. HPV infection will cause vaginal pathogen reproduction and cervical epithelial dysplasia.