鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的疗效及对鼻纤毛传输功能的影响

Therapeutic Effects of Biyuan Tongqiao Granule Combined with Triamcinolone Acetonide Nasal Spray in the Treatment of Chronic Rhinosinusitis and its Effects on Nasal Mucociliary Transport Function

目的:探讨鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎(CRS)的疗效及对鼻纤毛传输功能的影响。方法:选取2015年4月至2017年1月南阳市第一人民医院收治的CRS患者126例,随机分为观察组和对照组,每组63例,2均采用曲安奈德鼻喷雾剂治疗,观察组在此基础上联合鼻渊通窍颗粒治疗,2组均连续治疗10周。比较2组临床治疗效果;评价并比较2组临床症候评分变化;检测并比较2组鼻纤毛传输功能和炎性因子水平变化。结果:观察组总有效率为87.30%,较对照组的71.43%显著升高(P<0.05);与治疗前比较,治疗后2组头晕头痛、流涕、鼻塞、嗅觉下降和喷嚏等临床症候评分均显著降低,且观察组低于对照组(P<0.05或P<0.01);与治疗前比较,治疗后2组MTT均显著降低,且观察组低于对照组(P<0.01);与治疗前比较,治疗后2组IL-2、IL-5、IL-6、IL-8水平均显著下降,且观察组低于对照组(P<0.05或P<0.01)。结论:鼻渊通窍颗粒联合曲安奈德鼻喷雾剂能提高CRS患者鼻纤毛传输功能,降低患者炎性反应,缓解患者临床症状,临床效果显著。

Objective： To explore the efficacy of Biyuan Tongqiao granule combined with triamcinolone acetonide nasal spray in the treatment of chronic rhinosinusitis（ CRS） and its effects on nasal mucociliary transport function. Methods： A total of 126 cases of CRS patients who were treated in our hospital from April 2015 to January 2017 were selected and randomly divided into treatment group（ n = 63） and control group（ n = 63）. The 2 groups were treated with triamcinolone acetonide nasal spray,and the treatment group was treated with Biyuan Tongqiao granules on this basis. The 2 groups were treated continuously for 10 weeks. The clinical efficacy of the 2 groups was compared. The changes of clinical symptom scores in the 2 groups were evaluated and compared. The changes of nasal mucociliary transmission and inflammatory factors between the 2 groups were detected and compared. Results： The total efficiency of the treatment group was 87. 30%,which was significantly higher than 71. 43% of the control group（ P〈0. 05）;compared with that before treatment,the scores of clinical symptom such as dizziness headache,nasal discharge,nasal congestion,olfaction decline and sneezing of the 2 groups after treatment significantly reduced,and the treatment group was lower than the control group（ P〈0. 05 or P〈0. 01）; compared with that before treatment. MTT of the 2 groups after treatment significantly decreased,and the treatment group was lower than the control group（ P〈0. 01）; compared with that before treatment,the levels of IL-2,IL-5,IL-6,IL-8 of the 2 groups after treatment significantly decreased,and the treatment group was lower than the control group（ P〈0. 05 or P〈0. 01）. Conclusion： Biyuan Tongqiao granule combined with triamcinolone acetonide nasal spray can improve the nasal mucociliary transport function of CRS patients,reduce the inflammation,relieve the clinical symptoms with remarkable efficacy.