现代骨科临床应用补肾壮筋汤的Meta分析

Meta-analysis on Bushenzhuangjin Decoction in orthopaedics clinical application

目的:系统评价补肾壮筋汤治疗骨科疾病的临床疗效,以循证医学角度为其临床应用提供客观依据。方法:计算机检索2016年5月1日以前PubMed、Embase、Medline、Cochrane图书馆、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、万方数据库(Wanfang Database)、维普中文科技期刊数据库(VIP)关于补肾壮筋汤治疗骨科疾病的文献,纳入文献的方法学质量采用改良Jadad量表评价,提取各研究中的数据并进行总体效应量合并,并将这些研究的数据通过Review Manager 5.3软件进行Meta分析。结果:补肾壮筋汤治疗骨关节炎的早期随访情况,补肾壮筋汤与阳性治疗对照组比较,2组比较差异无统计学意义[RR=1.07;95%CI:(0.99,1.15),P=0.09];补肾壮筋汤治疗下腰痛的早期随访情况,补肾壮筋汤与阳性治疗对照组比较,2组比较差异有统计学意义[RR=1.33;95%CI:(1.19,1.50),P<0.00001]。结论:补肾壮筋汤在骨科疾病治疗中具有一定优势,但研究结果存在一定局限性,希望开展更多大样本高质量的临床研究加以验证。

Objective： To assess Bushenzhuangjin Decoction for orthopaedics clinical application from evidence-based medicine.Methods： According to the computer-based online search,articles of PubMed,Embase,Medline,Cochrane Library,CBM,CNKI,Wanfang Database and VIP published before May lst,2016 were searched for Bushen Zhuangjin Decoction in orthopaedics clinical application. Seven studies were abstracted and synthesized by Review Manager 5. 3 for Meta-analysis. Results： Compared with positive control group,Bushenzhuangjin decoction had equal outcome for osteoarthritis at early stage follow-up [RR = 1. 07;95% CI：（ 0. 99,1. 15）,P = 0. 09]. However,Bushenzhuangjin decoction had better outcome than positive control group at early stage follow-up [RR = 1. 33; 95% CI：（ 1. 19,1. 50）,P〈0. 00001]. Conclusion： Bushenzhuangjin Decoction had advantage in treatment of orthopedic diseases. However,because of limition of the RCTs,the result of this study can be deviation. Therefore,more qualitified researches with large sample were expected to evaluate these resaults.