摘要
目的探讨慢性低度炎性反应与糖尿病肾脏疾病(DKD)的关系。方法将1254例2型糖尿病患者分为DKD组(487例)与单纯T2DM组(767例),DKD诊断依据:符合估算的肾小球滤过率(eGFR)〈60ml/(min·1.73m^2)或尿微量白蛋白/肌酐比值(UACR)≥30mg/g。通过自动分析仪测定血清慢性低度炎性反应指标:超敏C反应蛋白(hs.CRP)、白细胞总数、中性粒细胞百分比(NCR),并记录性别、病程、收缩压、舒张压等指标。利用多元Logistic回归分析慢性低度炎性反应指标与DKD的关系。结果与单纯T2DM组相比,DKD组的hs-CRP、白细胞总数、NCR均显著升高(t=~3.60、-3.43、3.10,P均〈0.01)。多元Logistic回归分析显示,hs—CRP(OR:1.116,95%CI:1.042~1.195,P=0.002)、白细胞总数(OR=1.092,95%CI:1.002~1.189,P=0.044)和NCR(OR:1.018,95%CI:1.004~1.033,P=0.015)与DKD风险增加显著相关。结论DKD的慢性低度炎性反应指标显著升高,hs—CRP、白细胞总数、NCR是DKD的独立危险因素。
Objective To explore the relationship between chronic low-grade inflammation and dia- betic kidney disease (DKD). Methods A total of 1 254 patients with type 2 diabetes mellitus (T2DM) were enrolled and divided into two groups:DKD group (487 cases) and T2DM group (767 cases). DKD was diagnosed if the estimated glomerular filtration rate (eGFR) were less than 60 ml/( min · 1.73 m2) or if the urine albumin creatinine ratio (UACR) were no less than 30 mg/g. Serum chronic low-grade inflam- mation indexes including high sensitive C-reactive protein (hs-CRP), total white blood cell count and neu- trophil percentage (NCR) were measured with an automatic analyzer. Sex, duration, systolic blood pres- sure, diastolic blood pressure and other indicators were recorded as well. Muhiple Logistic regression analy- sis was conducted to analyze the relationship between chronic low-grade inflammation indexes and DKD. Results The hs-CRP, total white blood cell count and NCR were significantly higher in DKD group than those in T2DM group ( t= - 3.60, - 3.43, 3.10, all P 〈 0.01 ). Multiple Logistic regression analysis showed that hs-CRP (OR =1. 116, 95% CI: 1.042-1. 195, P=0.002), total white blood cell count (0R=1.092, 95% CI: 1.002-1.189, P=0.044) and NCR (0R=1.018, 95% CI: 1.004-1.033, P = 0. 015) were related to the increased risk of DKD. Conclusions Chronic low-grade inflammation inde- xes are increased in DKD. Moreover, hs-CRP, total white blood cell count and NCR are independent risk factors of DKD.
作者
邓雪凤
曹雪亭
杨萍
王越
胡金波
杨淑敏
李启富
Deng Xuefeng;Cao Xueting;Yang Ping;Wang Yue;Hu Jinbo;Yang Shumin;Li Qifu(Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China)
出处
《国际内分泌代谢杂志》
2017年第6期373-375,380,共4页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目(81370954,81670785)
国家临床重点专科建设项目
重庆市基础科学与前沿技术研究专项(cstc2015jcyjBX0096)
重庆市社会事业与民生保障科技创新专项子课题(cstc2016shms-ztzx1003)
关键词
慢性低度炎症
糖尿病
糖尿病肾脏疾病
Chronic low-grade inflammation
Diabetes mellitus
Diabetic kidney disease