SIRT1与糖尿病相关肿瘤的关系

Association of SIRT1 with diabetes-related tumors

糖尿病不仅增加肿瘤的患病风险，而且促进肿瘤的复发和转移。沉默信息调节因子1（SIRT1）是机体的能量感受器，具有调节糖、脂代谢，抑制慢性非特异性炎性反应，改善胰岛素抵抗等作用，其表达及活性异常参与了糖尿病及其并发症的发生。同时近期研究发现SIRT1也与肿瘤的发生、发展密切相关。通过去乙酰化调节机制SIRT1可调控大量转录因子及组蛋白的活性，从而参与染色质沉默、细胞凋亡、自噬途径及DNA损伤修复的调控，是联系细胞能量代谢与染色质结构的关键蛋白，因而可能是联系糖尿病及糖尿病相关肿瘤的重要中介。积极干预糖尿病患者中SIRT1信号途径异常，可能具有降低肿瘤风险的作用。

It is reported that diabetes increases the prevalence of tumors and promotes the recur- rence and metastasis of tumors. Silent information regulator 1 （ SIRT1 ）, the energy sensor of cells, play im- portant roles in the regulations of glucolipid metabolism, inhibition of chronic non-specific inflammatory re- sponse, the improvement of insulin resistance. The abnormal expression and activities of SIRT1 play roles in diabetes and its complications. Recent studies also have found that SIRT1 acts in the initiation and progress of tumors. Through its deacetylation regulatory mechanism, SIRT1 regulates the activities of many transcrip- tion factors and histone, and therefore is involved in a large number of physiologic process of cells including chromatin silencing, apoptosis, autophagy, and the repair of DNA damage. SIRT1 is a key protein in the coupling of energy metabolism and chromatin structure. Therefore, SIRT1 may be a key player bridging dia- betes and diabetes-related tumors, and active intervention targeting the abnormal SIRT1 signaling pathways may reduce the risk of tumor in diabetes.