脑肠肽对肠屏障损伤的保护作用和机制

Protective effects of brain-gut peptides against intestinal barrier injury and mechanisms involved

脑肠肽(brain-gut peptide)在脑和胃肠道中双重分布,是具有神经递质和激素双重功能的小分子多肽.肠屏障损伤对各种危重疾病的预后有着严重的影响.脑肠肽可以通过调节紧密连接蛋白、促进上皮细胞增殖、抑制细胞凋亡、抑制炎症因子等方面,在维持肠屏障完整及肠道免疫防御中起重要作用.故本文就近年来脑肠肽对肠屏障损伤的保护及作用机制作一综述.

Brain-gut peptides, a group of small molecule polypeptides, have been found to distribute widely in the brain and the gastrointestinal system and act as both neurotransmitters and hormones. Intestinal barrier injury has a serious impact on the prognosis of critical diseases. Braingut peptides can modulate tight junction proteins,promote epithelial cell proliferation, and inhibit apoptosis and inflammatory cytokines, thus playing an important role in the maintenance of intestinal barrier and mucosal immunity. In this review, we discuss the protective effects of braingut peptides against intestinal barrier injury and the underlying mechanisms.