幽门螺杆菌根治术对合并幽门螺杆菌感染十二指肠溃疡患者胃窦炎症程度及炎症介质影响

Effect of Helicobacter pylori eradication therapy on degree of antral inflammation and inflammatory mediators in patients with Helicobacter pylori infection and duodenal ulcer

目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)根治术对合并幽门螺杆菌感染十二指肠溃疡(duodenal ulcer,DU)患者胃窦炎症程度及炎症介质影响.方法选取2014-09/2016-09间在绍兴市柯桥区齐贤医院和绍兴市中心医院接受治疗的DU合并H.pylori感染患者100例,患者均使用H.pylori根治四联方案进行治疗,观察患者胃窦的炎症程度、炎症介质的含量和H.pylori感染程度联系,观察患者治疗前后体内炎症程度和炎症介质含量变化情况.结果胃窦患者慢、急性的炎症和其H.pylori的感染程度呈正相关关系(r=0.267,P<0.05);H.pylori阳性患者其胃部丙二醛(malonaldehyde,MDA)、白介素-8(interleukin-8,IL-8)、超氧化物歧化酶(superoxide dismutase,SOD)和肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)的水平均高于阴性患者,对比差异有统计学意义(P<0.05);随着患者炎症程度变高,其炎症介质MDA、IL-8、SOD和TNF-α含量也逐渐升高,呈现出正相关的关系(r=0.941,P<0.05);经过治疗后,患者炎症程度和炎症介质含量均有明显改善,与治疗前对比差异有统计学意义(P<0.05).结论H.pylori根治术可明显改善DU合并H.

AIM To investigate the effect of Helicobacter pylori（H. pylori） eradication therapy on the degree of antral inflammation and inflammatory mediators in patients with H. pylori infection and duodenal ulcer（DU）.METHODS From September 2014 to September 2016, 100 patients with H. pylori infection and DU treated at the Qixian Hospital of Keqiao District and Shaoxing Central Hospital were included in this study. All the patients underwent H.pylori radical quadruple therapy. The degree of inflammation in the gastric antrum and the contents of inflammatory mediators were compared between before and after treatment.RESULTS The degree of chronic and acute inflammation in the gastric antrum was positively correlated with H. pylori infection（r = 0.267, P 〈 0.05）.The l evel s of malona ldehyde（MDA）,interleukin-8（IL-8）, superoxide dismutase（SOD）, and tumor necrosis factor-α（TNF-α）were significantly higher in H. pylori positive patients than in H. pylori negative patients（P 〈0.05）. As the degree of inflammation increased,the levels of MDA, IL-8, SOD, and TNF-αwere also gradually increased, and there was a positive relationship between the degree of inflammation and the levels of inflammatory mediators（r = 0.941, P 〈 0.05）. After treatment,both the degree of inflammation and the levels of inflammatory mediators were improved significantly（P 〈 0.05）.CONCLUSION H. pylori eradication therapy can obviously improve the degree of inflammation and the contents of inflammatory mediators in H. pylori infected patients with DU.