阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的影响

Effects of atorvastatin on carotid atherosclerotic plaque in the patients with acute cerebral infarction

目的探讨阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的影响。方法选自我院于2015年6月~2016年6月期间收治的急性脑梗死患者颈动脉粥样硬化斑块60例,按照随机数字表法分为观察组与对照组各30例。对照组患者给予常规治疗,观察组在对照组基础上结合阿托伐他汀治疗。4周为一个疗程。比较两组患者治疗前后IMT以及血脂各项指标TC、TG、HDL-C、LDL-C的变化情况。结果两组患者治疗前IMT比较差异无统计学意义(P>0.05);治疗后,观察组患者的IMT水平为(1.22±0.56)mm,显著低于治疗前及对照组,差异有统计学意义(P<0.05)。两组患者治疗前TC、TG、HDL-C、LDL-C比较无统计学差异(P>0.05);治疗后,观察组患者的TC为(4.15±1.17)mmol/L、TG为(1.43±0.49)mmol/L、HDL-C为(1.33±0.47)mmol/L、LDL-C水平为(2.39±0.56)mmol/L,与治疗前及对照组分别比较,差异有统计学意义(P<0.05)。且观察组患者治疗后的TC、TG、HDL-C、LDL-C较对照组改善更显著(P<0.05)。结论阿托伐他汀治疗脑梗死颈动脉粥样硬化不仅可以降低血脂水平,还可以缩小颈动脉粥样硬化斑块,疗效确切,值得临床推广应用。

Objective To investigate the effect of atorvastatin on carotid atheroselerotic plaque in the patients with acute cerebral infarction. Methods 60 patients with carotid atheroselerotic plaque who were admitted to our hospital from June 2015 to June 2016 were selected. According to the random number table method, the patients were assigned to the observation group and the control group, with 30 patients in each group. Patients in the control group were given routine therapy, and patients in the observation group was given atorvastatin on the basis of the control group. The course of treatment was 4 weeks. The changes of IMT and lipid indices such as TC, TG, HDL-C and LDL-C were compared between the two groups before and after treatment. Results There was no statistically significant difference in IMT between the two groups before treatment（P〉0.05）; after treatment, the IMT level in the observation group was （1.22±0.56）mm, which was significantly lower than that before the treatment and in the control group. The difference was statistically significant（P〈0.05）. There was no statistically significant difference in TC, TG, HDL-C and LDL-C between the two groups before treatment（P〉0.05）; after treatment, TC in the observation group was （4.15±1.17） mmol/L,TG was （1.43 ＋0.49）retool/L, HDL-C was （1.33±0.47）mmol/L, LDL-C level was（2.39±0.56） mmol/L.The differences compared with those before the treatment and in the control group were statistically significant（P〈0.05）. The levels of TC, TG, HDL-C and LDL-C in the observation group were significantly higher than those in the control group after the treatment（P〈0.05）. Conclusion Atorvastatin in the treatment of cerebral infarction carotid atherosclerosis can not only reduce blood lipid levels, but also can reduce carotid atherosclerotic plaque. The curative effect is exact and it is worthy of clinical promotion and application.