二甲双胍、参芪降糖颗粒联用治疗新诊断2型糖尿病的疗效评估

Evaluation on the efficacy of metformin combined with Shenqi Jiangtang Granules in the treatment of newly diagnosed type 2 diabetes mellitus

目的评估二甲双胍、参芪降糖颗粒联合应用治疗新诊断2型糖尿病的临床效果。方法选择2016年9月~2017年2月我院收治的40例初诊为2型糖尿病患者作为研究对象,随机分为对照组与观察组,各20例。对照组单用二甲双胍治疗,观察组在对照组治疗的基础上加用参芪降糖颗粒,经过3个月治疗后,比较两组患者的临床治疗效果。结果治疗后,两组患者的空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(glycosylated hemoglobin,Hb Alc)、空腹胰岛素(fasting insulin,FINS)水平、胰岛素抵抗指数(HOMA-IR)及总胆固醇(Total cholesterol,TC)、甘油三酯(total glyceride,TG)、低密度脂蛋白(low density lipoprotein,LDL-C)均较治疗前下降,高密度脂蛋白(high density lipoprotein,HDL-C)升高(P<0.05);治疗后观察组患者的FPG、Hb Alc、FINS、HOMA-IR及TC、TG、LDL-C较对照组明显降低、HDL-C明显升高(P<0.05)。观察组总体有效率显著高于对照组(P<0.05)。结论二甲双胍、参芪降糖颗粒联用能明显改善2型糖尿病患者糖脂代谢及胰岛素抵抗,且疗效优于单用二甲双胍。

Objective To evaluate the clinical effect of metformin combined with Shenqi Jiangtang Granules in the treatment of newly diagnosed type 2 diabetes mellitus. Methods A total of 40 patients with the first diagnosis of type 2 diabetes mellitus who were admitted to our hospital from September 2016 to February 2017 were selected as research subjects and were randomly divided into control group and observation group, with 20 patients in each group. The con- trol group was treated with metformin alone, and the observation group was further treated with Shenqi Jiangtang Gran- ules on the basis of the control group. After 3 months of treatment, the clinical efficacy of the two groups of patients was compared. Results After treatment, the fasting plasma glucose（FPG）, glycosylated hemoglobin （HbAlc）, fast- ing insulin （FINS）levels, insulin resistance index （HOMA-IR） and total cholesterol （TC）, triglyceride （TG）, and low density lipoprotein （LDL-C） after the treatment were all decreased compared with those before the treatment in both groups, while high density lipoprotein（HDL-C） was increased（P〈0.05）; FPG, HbAlc, FINS, HOMA-IR, and TC, TG, LDL-C in the observation group after the treatment were significantly lower than those in the control group, while HDL-C was significantly increased（P〈0.05）. The overall effective rate in the observation group was significantly higher than that in the control group（P〈0.05）. Conclusion Metformin combined with Shenqi Jiangtang Granules can signifi- cantly improve glucose and lipid metabolism and insulin resistance in patients with type 2 diabetes mellitus, and its ef- ficacy is better than that of mefformin alone.