血清淀粉样蛋白A在不同类型手足口病急性期中的应用

Application of serum amyloid A in different types of hand-foot-mouth disease at acute phase

目的探讨血清淀粉样蛋白A(SAA)在手足口病急性期轻症患儿、危重症[包括肠道病毒71型(Enterovirus71,EV 71)、柯萨奇病毒A组16(Coxsackievirus A 16,Cox A 16)型]感染患儿中的诊断价值。方法选取2015年7~12月间轻症手足口患儿442例,危重症患儿85例,其中包括EV71感染患儿57例、Cox A16感染患儿28例,入院24 h内检测各组患儿SAA水平,并进行统计学对比分析。结果轻症组手足口病患儿SAA水平显著高于危重症组,差异有统计学意义(P<0.05);危重症组手足口患儿EV71型、Cox A16型SSA水平组间比较,差异无统计学意义(P>0.05)。结论 SAA在手足口病患儿急性期明显升高,而且在Cox A16组、EV71组中升高低于轻症组。SAA在儿童手足口病的辅助诊断、轻重症的早期鉴别诊断以及治疗中起到重要作用,值得临床广泛应用。

Objective To investigate the diagnostic value of serum amyloid A （SAA） in the children with mild acute hand-foot-mouth disease, critical illness [including enterovirus type 71 （EV 71）, and Coxsackievirus type A 16 （CoxA 16）]. Methods From July to December 2015, 442 children with mild hand-foot-mouth disease and 85 critically ill children were selected, including 57 children with EV71 infection, and 28 children with CoxA16 infection. The level of SAA in each group was detected within 24 hours after admission, and statistically comparative analysis was performed. Results The level of SAA in children with mild hand-foot-mouth disease was significantly higher than that in critically ill group, and the difference was statistically significant （P〈0.05）.There was no statistically significant difference in the levels of SAA of type EVT1 and type CoxA16 in the children with hand-foot-mouth disease in the critically ill group （P〉0.05）. Conclusion SAA in children with hand-foot-mouth disease in the acute phase is significantly increased, and the increase in the CoxA16 group and EV71 group is lower than the mild group. SAA plays an important role in the adjuvant diagnosis of hand-foot-mouth disease in children, as well as in the early differentiated diagnosis and treatment of mild and severe diseases, which is worthy of widespread clinical application.