TTF-1、NapsinA、CK7、P63和CK5/6在肺癌活检组织学分型诊断的价值

Diagnostic Value of TTF-1, Napsin A, CK7, P63 and CK5/6 in Lung Cancer Biopsy Tissue Typing

目的分析在肺癌活检的组织学分型诊断中应用CK5/6、TTF-1、P63、Napsin A以及CK7的价值。方法选在我院进行支气管镜检与肺穿刺活检患者200例,其中195例患者为原发性肺癌,5例患者为转移性腺癌,回顾分析患者的临床资料。结果在AC患者中,TTF-1、Napsin A、CK7占比明显要比SCC、SCLC占比大,经过对比,差异有统计学意义,P<0.05;在SCC患者中P63、CK5/6占比明显要比AC、SCLC大,差异有统计学意义,P<0.05;AC、SCC患者中CK7、CK5/6占比明显要比SCLC大,差异有统计学意义,P<0.05。结论在肺癌活检的组织学分型诊断中联合应用CK5/6、TTF-1、P63、Napsin A以及CK7,能够给临床治疗提供参考。

Objective To analyze the value of CK5/6, TW-1, P63, Napsin A and CK7 in the histological diagnosis of lung cancer biopsy. Methods 200 cases of bronchoscopy and lung biopsy.were selected in our hospital, of which 195 cases were primary lung cancer and 5 cases were metastatic adenocarcinoma. The clinical data of the patients were retrospectively analyzed. Results In AC patients, the proportion of TTF-1, Napsin A and CK7 was significantly higher than that of SCC and SCLC. After comparison, the difference was statistically significant, P 〈 0.05; In SCC patients, the proportion of P63 and CK5/6 was significantly higher than that of AC and SCLC, and the difference was statistically significant, P 〈 0.05; The proportion of CK7 and CK5/6 in patients with AC and SCC was significantly higher than that of SCLC, and the difference was statistically significant, P 〈 0.05. Conclusion The combination of CK5/6, TTF-1, P63, Napsin A and CK7 in the diagnosis of lung cancer biopsy can provide reference for clinical treatment.