宫腔镜联合屈螺酮炔雌醇治疗子宫内膜息肉的临床疗效观察

Clinical Observation on Hysteroscopy Combined With Drospirenone and Ethinylestradiol in the Treatment of Endometrial Polyp

目的探讨宫腔镜联合屈螺酮炔雌醇治疗子宫内膜息肉的临床疗效。方法按照随机数字表法将2014年2月—2017年5月84例子宫内膜息肉患者分组。对照组采用宫腔镜手术治疗,手术+药物组采用宫腔镜联合屈螺酮炔雌醇治疗。比较两组成功妊娠率;术后子宫内膜厚度、术后平均住院天数;术后乳房胀痛、出血、过度水化综合征发生率。结果手术+药物组成功妊娠率高于对照组,P<0.05。其中,手术+药物组成功妊娠率50.00%;对照组成功妊娠率35.71%。手术+药物组术后子宫内膜厚度(9.42±3.52)mm,高于对照组的(6.12±1.52)mm,术后平均住院天数少于对照组,P<0.05。手术+药物组术后并发症发生率低于对照组,P<0.05。结论宫腔镜联合屈螺酮炔雌醇对于子宫内膜息肉治疗的临床疗效确切,可有效增厚子宫内膜,减少并发症发生,缩短住院时间,提高妊娠率。

[Abstract] Objective To investigate the clinical effect of hysteroscopy combined with drospirenone and ethinylestradiol on endometrial polyps. Methods From February 2014 to May 2017, a total of 84 patients with endometrial polyps were divided into two groups in accordance with the random number table method. The control group was treated with hysteroscopy, and the surgery＋drug group was treated with hysteroscopy combined with drospirenone and ethinylestradiol. The successful pregnancy rate; postoperative endometrial thickness, postoperative average length of hospital stay; postoperative breast tenderness, bleeding, excessive hydration syndrome incidence between two groups were compared. Results The pregnancy rate of surgery＋drug group was higher than that of the control group, P〈0.05. Among them, the pregnancy rate of surgery＋drug group was 50.00%; the pregnancy rate of control group was 35.71%. The postoperative endometrial thickness was （9.42 ±3.52）mm in the surgery group and （6.12±1.52） mm in the control group. The average number of hospitalizations of surgery＋drug group was fewer than that of the control group （P〈0.05）. The incidence of postoperative complications was lower in the surgery＋drug group than in the control group （P〈0.05）. Conclusion Hysteroscopy combined with drospirenone and ethinylestradiol can achieve exact clinical efficacy in the treatment of endometrial polyps, they can effectively thicken the endometrium, reduce the incidence of complications, shorten the hospital stay, improve the pregnancy rate.