芍药汤加减治疗活动性溃疡性结肠炎18例

Treatment of 18 Cases of Active Ulcerative Colitis With Modified Shaoyao Decoction

目的观察以芍药汤为基本方加减治疗活动性溃疡性结肠炎的临床疗效,以及服药后对患者血清TNF-α、IL-8水平的影响。方法选取活动性溃疡性结肠炎患者36例,随机等分为两组。治疗组采用芍药汤加减方治疗,对照组采用西药柳氮磺胺吡啶肠溶片治疗,采用ELISA法测定血清TNF-α、IL-8水平,以2周为一个疗程,2个疗程后评价临床疗效与指标的差异。结果治疗前后比较,对照组与治疗组间及组内Mayo评分及血清TNF-α、IL-8水平差异均有统计学意义(P<0.05)。结论服用芍药汤加减方可改善溃疡性结肠炎临床症状及提高治疗效果,可作为溃疡性结肠炎的有效治疗方法。

Objective To observe the clinical effect of Shaoyao decoctionin the treatment of active ulcerative colitis, and its effect on the serum levels of TNF-α and IL-8. Methods 36 patients with active ulcerative colitis were randomly divided into two groups.The treatment group was treated with Shaoyao decoction,the control group was treated with sulfasalazine, serum levelsof TNF-α and IL-8 were tested by ELISA. Two weeks were regarded as a treatmentcourse, differences in clinical efficacy and indexes were evaluated after two courses. Results After treatment, Mayo scores and serum TNF-α, IL-8 levels between the treatment group and the control group and withingroup had significant differences （P〈0.05）. Conclusion The effect of Shaoyao decoctionin the treatment of ulcerative colitisissignificant.