摘要
结肠癌干细胞具有不受控的自我更新能力和致结肠癌形成潜能，可抵抗常规抗肿瘤治疗方法。胰岛素抵抗相关因子主要包括脂联素、瘦素、各种炎症因子等，各种胰岛素抵抗相关因子可通过不同的作用机制对结肠癌干细胞的增殖、凋亡、迁移及致癌性等产生不同的影响。了解胰岛素抵抗相关因子与结肠癌干细胞的关系，可为结肠癌提供新的治疗方法。
Colon cancer stem cells have uncontrolled self-renewal capabilities, a potential of forming colon cancer and resistance to conventional anti-tumor therapy. Insulin resistance related factors mainly include adiponectin, leptin and various inflammatory factors. Various insulin resistance related factors have different effects on the proliferation, apoptosis, migration, carcinogenesis of colon cancer stem cells through different mechanisms. Understanding the relationship between various insulin resistance related factors and colon cancer stem cells can provide a new treatment for colon cancer.
出处
《国际肿瘤学杂志》
CAS
2017年第10期790-793,共4页
Journal of International Oncology
基金
安徽省自然科学基金（1508085MH150）
关键词
结肠肿瘤
干细胞
胰岛素抵抗
Colonic neoplasms
Stem cells
Insulin resistance
