短暂性脑缺血发作患者血浆高半胱氨酸与尿酸水平相关性研究

The Levels and Correlation Studies of Homocysteine and Uric Acid in Plasma in Patients with Transient Ischemic Attack

目的探究短暂性脑缺血发作(transient ischemic attack,TIA)患者血浆同型半胱氨酸(homocysteine,HCY)和尿酸(uric acid,UA)的水平及二者的相关性。方法收集110例TIA患者及115例健康查体者血液标本,分别采用荧光免疫法、比色法测定血浆HCY、UA的水平。结果 TIA组血浆HCY和UA浓度分别为(20.47±7.32)μmol/L和(341.17±84.31)μmol/L;对照组血浆HCY和UA浓度分别为(15.28±4.62)μmol/L和(298.67±64.59)μmol/L。TIA组患者HCY、UA表达显著高于对照组(均P<0.001)。Pearson相关分析示TIA组HCY、UA二者呈正相关(r=0.239,P=0.012)。Logistic回归分析示,尿酸[比值比(odds ratio,OR)1.017,95%可信区间(confidence interval,CI)1.012~1.023,P<0.001]、HCY(OR 1.077,95%CI 1.003~1.156,P=0.041)为TIA危险因素。结论 TIA患者血浆HCY、UA水平均增高且二者具有相关性。

Objective To investigate the levels and correlation of homocysteine （HCY） and uric acid （UA） in blood plasma of patients with transient ischemic attack （TIA）. Methods The blood preparation of 110 patients with TIA and 115 normal subjects were collected. The levels of HCY and UA were respectively measured by fluorescence immunoassay and colorimetry. Results The levels of the HCY and UA in plasma of TIA patients were （20.47±7.32） μmol/L and （341.17±84.31） μmol/L respectively. The levels of HCY and UA in the common group plasma were （15.28±4.62） μmol/L and （298.67±64.59） μmol/L respectively. The contents of the HCY and UA in plasma of TIA group were significantly higher than that of the common group （All P＜0.001）. The Pearson correlation analysis showed that there was a positive correlation between HCY and UA in plasma of TIA patients （r=0.239, P=0.012）. Logistic regression analysis revealed that the UA [odds ratio （OR） 1.017, 95% confidence interval （CI） 1.012-1.023, P＜0.001] and HCY （OR 1.077, 95%CI 1.003-1.156, P=0.041）were the independent risk factors for TIA. Conclusion The contents of the HCY and UA in plasma of TIA group were both increased and were associated with each other.