布地奈德辅助治疗喘息性慢性支气管炎的可行性分析

Feasibility analysis of budesonide with adjuvant therapy for asthmatic chronic bronchitis

目的分析雾化吸入布地奈德辅联合复方异丙托溴铵治疗喘息性慢性支气管炎的可行性。方法随机选取我院于2015年6月～2017年6月收治的喘息性慢性支气管炎患者68例,并对其临床资料进行回顾性分析,将采用雾化吸入复方异丙托溴铵进行治疗的34例患者作为对照组,将加用布地奈德进行治疗的34例患者作为观察组,对两组的治疗效果和不良反应发生情况进行观察比较。结果观察组的治疗总有效率为94.12%(32/34),对照组的治疗总有效率为82.35%(28/34)(P<0.05);治疗后,观察组肺部湿啰音消失时间为(5.52±1.29)d、喘息消失时间为(3.67±1.51)d、咳嗽消失时间为(4.69±2.42)d及气促时间为(3.49±1.18)d,明显少于对照组(P<0.05);观察组和对照组在治疗过程中,均未发现明显的不良反应。结论对喘息性慢性支气管炎患者应用雾化吸入布地奈德和复方异丙托溴铵进行治疗,其治疗效果确切,有效缓解患者的临床症状,且不会增加不良反应,效果安全可靠,值得临床应用和推广。

Objective To analyze the feasibility of aerosol inhalation of budesonide combined with compound ipratropium bromide in the treatment of chronic asthmatic bronchitis. Methods 68 cases of asthmatic chronic bronchitis who were treated in our hospital from June 2015 to June 20t7 were selected randomly.The clinical data of the patients were analyzed retrospectively.34 patients treated with aerosolized ipratropium bromide were selected as the control group,and 34 patients treated with budesonide were selected as the observation group.The therapeutic effects and adverse reactions of the two groups were observed and compared. Results The total effective rate of the observation group was 94.12%（32/34）,and the total effective rate of the control group was 82.35%（28/34） （P 〈 0.05）;After treatment,in the observation group,disappearance time of pulmonary tales was （5.52 ± 1.29）d,wheezing disappearance time was（3.67 ± 1.51）d,the disappearance time of cough was （4.69 ± 2.42）d and shortness of breath time was（3.49 ± 1.18）d,which was significantly less than that of the control group（P 〈 0.05）.No obvious adverse reactions were observed in the observation group and the control group during the course of treatment. Conclusion Nebulized budesonide combined with compound isopropyl tiotropium bromide in treatment of asthmatic patients with chronic bronchitis has a good effect,and effectively relieve the clinical symptoms of the patients,without increasing adverse reactions,the effect is safe and reliable,worthy of clinical application and promotion.