对氨基水杨酸异烟肼、左氧氟沙星联合化疗对复治肺结核病的疗效分析及安全性评价

Efficacy analysis and safety evaluation of p-aminosalicylic acid isoniazid and levofloxacin combined with chemotherapy in the treatment of pulmonary tuberculosis

目的探究对氨基水杨酸异烟肼、左氧氟沙星联合化疗对复治肺结核病的疗效及安全性。方法选取2015年1月～2016年6月我院收治的复治涂阳肺结核患者84例作为研究对象,按随机数字表法分为对照组和观察组。对照组采取3HRZE/6HRE常规化疗方案,观察组在对照组治疗的基础上,加用对氨基水杨酸和左氧氟沙星治疗;统计两组患者痰涂片检查和胸片检查,计算痰涂片转阴率、病灶吸收情况、临床疗效及不良反应发生情况。结果与对照组相比,观察组患者在第6个月和第9个月的痰液阴转率显著增加(P<0.05);病灶明显吸收的比率和总吸收率增加(P<0.05);临床疗效显效率和总有效率显著增加(P<0.05);不良反应发生情况两组患者无统计学意义(P>0.05)。结论对氨基水杨酸异烟肼、左氧氟沙星联合化疗对复治肺结核病临床效果良好,值得推广。

Objective To investigate the efficacy and safety of p-aminosalicylic acid isoniazid and levofloxacin combined with chemotherapy in the treatment of pulmonary tuberculosis. Methods 84 patients with smear-positive pulmonary tuberculosis treated in our hospital from January 2015 to June 2016 were selected as the subjects. According to the random number table method,84 patients were divided into control group and observation group.The control group were received 3HRZE/6HRE conventional chemotherapy regimen,the observation group were treated with aminosalicylic acid and levofloxacin treatment Based on the treatment in control group.Sputum smear examination and chest X-ray examination of two groups were counted.The sputum smear negative rate,lesion absorption,clinical efficacy and adverse reactions were calculated. Results Compared with the control group,the sputum negative conversion rate in the observation group at sixth months and ninth months was significantly increased （P 〈 0.05）. The rate of significant absorption of the lesion and the total rate of absorption were increased （P 〈 0.05）;The effective rate of clinical efficacy and the total effective rate were increased significantly （P 〈 0.05）.There was no significant difference in adverse events between the two groups （ P 〉 0.05 ）. Conclusion The combination of isofluryl salicylate and levofloxacin in the treatment of pulmonary tuberculosis has a good clinical effect and is worthy of promotion.