血压干预对妊娠期高血压患者尿微量白蛋白变化与预后关系的回顾性分析

Retrospective analysis of the relationship between microalbuminuria and prognosis of hypertensive disorder complicating pregnancy by blood pressure intervention

目的对妊娠期高血压患者的尿微量白蛋白变化进行回顾性分析,探究血压干预对妊娠期高血压患者的尿微量白蛋白变化以及预后所产生的影响。方法从2015年5月～2016年10月在我院进行产检和诊治的妊娠期高血压患者中随机选取90例患者作为本次的研究对象,将这90例患者随机分为干预组和对照组两组,干预组给予硝苯地平控释片对患者血压进行干预,对照组患者不予血压干预。对比两组患者在入院时、产后24h以及产后4d尿微量白蛋白排泄率、白天血压、夜晚血压以及新生儿1min Apgar评分。结果入院时,两组患者在尿微量白蛋白的排泄率、白天血压、夜晚血压方面比较,差异有统计学意义(P<0.05);而产后24h和产后42d,与不予血压干预的对照组相比,给予血压干预的干预组患者妊娠期高血压症状得到显著有效的控制,两组患者在产后24h、产后42d尿微量白蛋白排泄率、白天血压、夜晚血压以及新生儿1min Apgar评分均有统计学意义(P<0.05)。结论对妊娠期高血压患者进行血压干预能够很好的控制住患者的妊娠期高血压,并且对新生儿1min Apgar评分也具有很深远的影响,因此,血压干预值得临床推广。

Objective The changes of microalbuminuria in patients with gestational pregnancy were analyzed retrospectively to investigate the effect of blood pressure intervention on mieroalbuminuria and prognosis in patients with hypertensive disorder complicating pregnancy. Methods From May 2015 to October 2016,90 cases of gestational pregnancy diagnosed and treated in our hospital were randomly selected as the subjects of this study,all the patients were randomly divided into intervention group and control group,the patients of intervention group were given Nifedipine Controlled Release Tablets to intervene the blood pressure of the patients,while the patients of control group were given no blood pressure intervention.The urinary albumin excretion rate,daytime blood pressure,night blood pressure,and neonatal lmin Apgar scores were compared between the two groups at admission,24 hours postpartum,and 42 days after delivery. Results At admission,there were no differences in urinary albumin excretion rate,daytime blood pressure,and night blood pressure between the two groups,and there was no statistical signifieance,（P 〉 0.05）.But after 24 hours and 42 days postpartum,compared with the control group without the intervention of blood pressure,blood pressure during pregnancy given intervention group patients with hypertension symptoms were controlled significantly,the urinary albumin excretion rate, daytime blood pressure,night blood pressure,and neonatal lmin Apgar scores of the two groups at 24 hours postpartum,and 42 days after delivery were significant the difference,（P 〈 0.05）,there was statistical significance. Conclusion The blood pressure intervention on patients with gestational hypertension can be well controlled during pregnancy in patients with hypertension,and the scores of neonatal lmin Apgar also has a very profound impact,therefore,blood pressure intervention is worthy of clinical promotion.