VEGF和EGFL在骨血管生成中的作用

The Role of VEGF and EGFL in Bone Angiogenesis

骨血管分布密集且广泛,在骨的生长发育中,骨血管不仅提供必需的氧和营养物质,而且通过调节各种骨细胞和血管细胞间的相互作用,为骨形成提供必要的刺激信号。大量研究表明,局部血管的变化与许多骨疾病的发展密不可分。骨血管生成过程中受大量因子的调节,该文主要对血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子样家族成员[epidermal growth factor(EGF)-like family members,EGFL]在调节骨血管生成中的作用作一综述,旨在为相关骨疾病的治疗提供理论基础。

Bone is a highly vascularized tissue containing an extensive vascular network of large vessels and capillaries, which provide oxygen and nutrients for bone formation and development through regulation of different signaling pathways between bone cells and endothelial cells. Numbers of studies have proved that the variation of vasculature are closely related to the development of many bone diseases. Many factors play essential roles in the regulation of bone angiogenesis. This study mainly reviewed the functions of vascular endothelial growth factor （VEGF） and epidermal growth factor （EGF）-like family members （EGFL） in the regulation of bone angiogenesis, providing more understanding of the treatment of relevant bone diseases.