多索茶碱联合氨溴索治疗急性发作期慢性支气管炎疗效及对肺功能、炎症因子水平的影响

Efficacy of doxofylline combined with ambroxol on acute exacerbation of chronic bronchitis and its effects on pulmonary function,inflammation factors levels

目的探讨多索茶碱联合氨溴索治疗急性发作期慢性支气管炎疗效及肺功能、炎症因子水平的影响。方法选取102例急性发作期慢性支气管炎患者随机分为两组,均接受常规治疗,其中51例患者给予氨溴索治疗为常规组,另51例患者给予氨溴索+多索茶碱治疗为联合组,两组均治疗1周,观察其对两组患者临床疗效、肺功能、炎症因子水平及不良反应的影响。结果联合组和常规组临床总有效率分别为(94.12%和78.43%,P<0.05);两组治疗后的FVC、FEV1及FEV1/FVC显著高于治疗前(P<0.05),且联合组上述指标改善程度高于常规组(P<0.05);联合组治疗后的IL-6、IL-8及TNF-α水平显著高于治疗前及常规组治疗后(P<0.05);两组治疗期间均未见明显不良反应。结论急性发作期慢性支气管炎患者接受多索茶碱联合氨溴索治疗后,疗效显著,对患者肺功能提高、炎症水平改善具有积极影响。

Objective: To explore the efficacy of doxofylline combined with ambroxol in treatment of acute exacerbation of chronic bronchitis and its effects on pulmonary function and inflammatory factors levels. Methods: 102 cases of patients with acute exacerbation of chronic bronchitis were selected and randomly divided into the two groups: the routine group( n= 51,treated with ambroxol) and the combined group( n = 51,treated with ambroxol and doxofylline),and both groups were given the routine treatment and were treated for A week. The clinical efficacy,pulmonary function,inflammatory factors levels and adverse reactions were observed in the two groups. Results: The total effective rates of the combined group and the routine group were 94. 12% and 78. 43% respectively( P < 0. 05). The levels of FVC,FEV1 and FEV1/FVC after treatment were significantly higher than those before treatment in the two groups( P < 0. 05),and the improvement of the above indexes in the combined group was higher than that in the routine group( P < 0. 05). The levels of IL-6,IL-8 and TNF-α in the combined group after treatment were significantly higher than those before treatment and those in the routine group after treatment( P < 0. 05). There was no obvious adverse reaction between the two groups. Conclusions: Doxofylline combined with ambroxol in patients with acute exacerbation of chronic bronchitis can have a significant efficacy,and have positive effects on the pulmonary function and inflammation levels.