小RNA病毒2C基因及其编码蛋白的研究进展

Research advances in picornavirus 2C gene and its encoding protein

小RNA病毒2C基因保守性较高,其编码的2C蛋白是病毒的非结构蛋白,在小RNA病毒复制过程较早出现,只有在小RNA病毒复制的过程中才能产生;具有AAA+族解旋酶活性,参与自噬通路入侵过程,诱导细胞炎症反应和细胞凋亡,与其他非结构蛋白如2B和3C相互作用从而参与致病进程等。本文对小RNA病毒2C基因及其编码蛋白的研究进展进行总结,以期为开展对其深入研究提供参考。

Picornaviridae 2 Cgene is relatively conservative,whose encoded protein is a non-structural protein.The 2 Cprotein is in an earlier detection and only can be detected during virus replicatin.The 2 Cprotein has multiple fuctions:the role of AAA+helicase activity,invasion cells by autophagy pathway,abduction cells on inflammation and apoptosis;the interaction with other proteins such as 2 Band 3 Cthat might be induced by 2 Cprotein,which can participate in the pathogenic process in a way.Above all,we mainly outline the reseach advances on Picornaviridae 2 Cgene and its encoded protein,in order to provide some superficial reference for its further study.