p16、p21、p53和PCNA在视网膜母细胞瘤中的表达

Expression of the p16,p21,p53 genes and PCNA in retinoblastoma

目的 研究 p16、p2 1、p5 3和增殖细胞核抗原 (proliferating cell nuclear antigen,PCNA )在视网膜母细胞瘤的表达。方法 对 36例视网膜母细胞瘤标本采用免疫组织化学方法观察 p16、p2 1、p5 3和 PCNA表达水平。结果 36例标本中 p16、p2 1、p5 3和 PCNA阳性检出率分别是阳性表达率在肿瘤的分化程度方面有显著差异 (P<0 .0 5 )。结论 p16、p2 1、p5 3和

Objective To investigate the correlation of p16,p21,p53 and proliferating cell nuclear antigen(PCNA) in retinoblastoma .Methods Immunohistochemical staining was used to determine the expression of the p16,p21,p53 and PCNA in 36 cases of retinoblastoma. Results The positive expression rates of the p16,p21,p53 and PCNA in retinoblastoma were 47.0%,50.0%,66.6%,61.1%. There was a significant different histopathological grades(P<0.05). Conclusion It is concluded that p16,p21,p53 and PCNA play an important role in the genesis and progression of retinoblastoma.