阿苯达唑联合吡喹酮治疗肝吸虫病出现黄疸的相关病因分析

Etiological analysis of jaundice caused by albendazole combined with praziquantel in the treatment of clonorchiasis

目的:探讨阿苯达唑片与吡喹酮片治疗肝吸虫病对胆红素代谢的影响。方法:收治肝吸虫病患者112例,随机分为两组,分别给予阿苯达唑片联合吡喹酮片与单独应用吡喹酮片治疗,比较两组治疗效果。结果:在苯达唑联合吡喹酮组,ALT、AST、TB无升高率高于吡喹酮组,两组ALT、AST差异有统计学意义(P<0.05),而TB水平差异无统计学意义(P>0.05)。两组虫卵转阴率和不良反应发生率差异无统计学意义(P>0.05)。结论:阿苯达唑片联合吡喹酮片治疗肝吸虫病有显著的临床疗效,且不良反应较少,可作为肝吸虫病治疗时的首选药物。

Objective：To explore the influence of albendazole combined with praziquantel in the treatment of clonorchiasis on bilirubin metabolism.Methods：112 patients with clonorchiasis were selected.They were randomly divided into two groups.They were treated with albendazole combined with praziquantel and single praziquantel treatment respectively.We compared the treatment effect of two groups.Results：In the albendazole combined with praziquantel group,the no increase rates of ALT,AST and TB were higher than those of the praziquantel group;the differences of ALT and AST were statistically significant（P〈0.05）,and there was no significant difference in the level of TB between groups（P〈0.05）.There were no significant differences in the rate of negative conversion of eggs and the incidence of adverse reactions between groups（P〈0.05）.Conclusion：The clinical efficacy of albendazole combined with praziquantel in the treatment of clonorchiasis was significant,and the adverse reactions were less.It can be used as the first choice in the treatment of clonorchiasis.