重复经颅磁刺激联合帕罗西汀治疗首发躯体形式障碍的效果观察

Effect of repetitive transcranial magnetic stimulation combined with paroxetine in the treatment of first onset somatoform disorder

目的:比较重复经颅磁刺激(rTMS)联合不同剂量帕罗西汀及单纯使用帕罗西汀对躯体形式障碍的疗效及安全性。方法:收治首发躯体形式障碍患者96例,随机分为观察一组、观察二组和对照组。分别给予rTMS联合10 mg帕罗西汀、rTMS联合20 mg帕罗西汀及单纯使用20 mg帕罗西汀治疗,比较3组治疗效果。结果:观察一组和观察二组治疗后HAMD评分与HAME评分均低于对照组(P<0.05)。观察一组与观察二组总有效率显著高于对照组(P<0.05)。观察一组、观察二组与对照组的不良反应发生率分别为15.64%、21.88%和43.75%,3组差异有统计学意义(P<0.05)。结论:rTMS联合小剂量(10 mg)帕罗西汀治疗首发躯体形式障碍具有疗效好、起效快、安全性高的优势。

Objective：To compare the efficacy and safety of repetitive transcranial magnetic stimulation（rTMS） combined with different doses of paroxetine and single use of paroxetine in the treatment of somatoform disorders.Methods：96 patients with first onset somatoform disorder were selected.They were randomly divided into the observation one group,the observation two group and the control group.They were treated with rTMS combined with 10 mg paroxetine,rTMS combined with 20 mg paroxetine and single use 20 mg paroxetine respectively.We compared the therapeutic effects of the 3 groups.Results：After treatment,the HAMD score and HAME score of the observation one group and the observation two group were lower than the control group（P〈0.05）.The total effective rates of the observation one group and the observation two group were significantly higher than the control group（P〈0.05）.The incidence of adverse reactions of the observation one group,the observation two group and the control group was 15.64%,21.88% and 43.75% respectively,and the differences among the 3 groups were statistically significant（P〈0.05）.Conclusion：RTMS combined with small dose（10 mg） paroxetine in the treatment of first onset somatoform disorder had obvious advantages,such as good efficacy,quick onset and high safety.