2型糖尿病患者治疗前后肺功能改变及其影响因素分析

Changes of lung function and its influencing factors in patients with type 2 diabetes mellitus before and after treatment

目的:探讨2型糖尿病患者治疗前后肺功能改变及其影响因素。方法:收治2型糖尿病患者100例为2型糖尿病组,选择健康人群40例为对照组。比较两组肺功能变化,并分析胰岛素治疗后糖尿病患者的肺功能变化。结果:2型糖尿病组的TLC、VC,FEV_1、MEF25、MEF50均低于对照组,FEV_1/FVC高于对照组(P<0.05)。FEV_1和BMI、并发症积分呈线性负相关,VC和BMI呈线性负相关,MEF25和病程、并发症积分呈线性负相关,DLCO和病程呈线性负相关,治疗后肺通气功能及弥散功能均好转,其中FEV_1、MVV、MEF25、DLCO、DLCO/VA差异有统计学意义(P<0.05)。结论:2型糖尿病患者存在限制性通气功能障碍、小气道功能及弥散功能减退,肺脏病变可能是糖尿病慢性并发症之一,控制血糖是治疗关键措施。

Objective：To explore the changes of lung function and its influencing factors in patients with type 2 diabetes mellitus before and after treatment.Methods：100 patients with type 2 diabetes were selected as the type 2 diabetes mellitus group.40 healthy subjects were selected as the control group.We compared the changes in lung function between the two groups,and analyzed changes in lung function in patients with diabetes after insulin treatment.Results：In the type 2 diabetes mellitus group,TLC,VC,FEV_1,MEF25 and MEF50 were lower than those in the control group,and FEV_1/FVC was higher than that in the control group（P〈0.05）.There was a linear negative correlation between FEV_1 and BMI and complication score;VC and BMI were linearly negatively correlated;there was a linear negative correlation between MEF25 and the course of disease and complication score;DLCO was negatively correlated with the course of disease;after the treatment,the pulmonary ventilation function and diffusion function were improved;among them,the differences of FEV_1,MVV,MEF25,DLCO and DLCO/VA were statistically significant（P〈0.05）.Conclusion：Restrictive ventilatory dysfunction,small airway function and diffuse dysfunction were present in type 2 diabetes mellitus patients.Lung lesions may be one of the chronic complications of diabetes.Controlling blood sugar was a key measure of treatment.