肝细胞脂肪变性与慢性乙型肝炎肝组织纤维化的相关性研究

Correlation between hepatocyte steatosis and liver fibrosis in patients with chronic hepatitis B

目的:探讨肝细胞脂肪变性与慢性乙型肝炎患者肝纤维化的关系。方法:收治慢性乙型肝炎并接受肝穿刺活检患者281例。肝组织标本常规行HE、Masson三色及网状纤维染色,观察其病理改变特点,观察肝细胞脂肪变性与其相关性;同时检测ALT及ALB、BMI,经多变量偏相关分析与脂肪变性的相关性。结果:肝细胞脂肪变性在G0期为34.4%,S0期为23.65%;ALT、ALB与脂肪变性没有相关性(P>0.05),BMI与脂肪变性没有相关性。肝门静脉的大小与脂肪变性无相关性(P>0.05)。结论:慢性乙肝脂肪变性率高发期是G0期及S0期,与肝纤维化早期改变密切相关。ALT、ALB、BMI的高低及肝门静脉的大小对脂肪变性的影响不大。

Objective：To investigate the relationship between hepatic steatosis and liver fibrosis in patients with chronic hepatitis B.Methods：281 patients with chronic hepatitis B who were treated with liver biopsy were selected,the liver tissue specimens were routinely stained with HE,Masson trichrome and reticular fibers.The pathological changes were observed and the correlation between hepatic steatosis and hepatic steatosis was observed.The correlation between ALT,ALB and BMI was analyzed by multivariate partial correlation analysis and steatosis.Results：Steatosis in G0 phase accounted for 34.4% and 23.65% during S0 phase,ALT and ALB were not associated with steatosis（P〉0.05）.There was no correlation between BMI and steatosis.There was no correlation between the size of hepatic portal vein and steatosis（P〉0.05）.Conclusion：The high incidence of steatosis in chronic hepatitis B is G0 and S0,which is closely related to the early change of liver fibrosis.The levels of ALT,ALB,BMI and the size of hepatic portal vein had little effect on steatosis.