胎儿颈项透明层厚度与染色体异常的相关性研究

Correlation between nuchal translucency thickness and chromosome abnormality in fetus

目的:探讨胎儿颈项透明层(NT)和染色体异常的相关性。方法:收治胎儿颈项透明层厚度>3 mm的孕妇80例,分别在孕早期进行胎儿绒毛、孕中期进行羊水穿刺检测,并通过细胞培养制成染色体核型,开展相关的诊断分析。结果:80例孕妇中,检查确定为染色体异常胎儿13例(16.25%)。当胎儿NT厚度>3 mm时,其核型异常的比例很高。结论:胎儿颈项透明层的厚度和染色体异常有直接的关系,随着透明层厚度的增加,染色体异常发生率越高。

Objective：To explore the correlation between nuchal translucency thickness and chromosome abnormality in fetus.Methods：80 pregnant women with nuchal translucency thickness greater than 3 mm were selected.We performed fetal villus testing in the early and amniocentesis tests in the metaphase.Chromosome karyotype was made by cell culture,and we carried out relevant diagnostic analysis.Results：In the 80 pregnant women,13 fetuses（16.25%） were confirmed as chromosomal abnormalities.When fetal NT thickness was greater than 3 mm,the proportion of abnormal karyotype was very high.Conclusion：There was a direct relationship between the thickness of the nuchal translucency and chromosomal abnormalities,with the increase of nuchal translucency thickness.The incidence of chromosome abnormality was higher.