优福定血清浓度的个体差异及其与疗效和毒性的相关性研究

Individual variation of serum concentration of new antitumour agent UFT and its correiations of concentration, effect and toxicity

给荷瘤小鼠灌胃优福定50,40和31mg/kg·d×8d,其血清呋喃氟尿嘧啶(FT)最低稳态浓度存在明显个体差异125只小鼠的FT浓度与抑瘤效应及体重增长率具有显著的相关性。文中讨论了监测血清FT浓度的必要性及其临床意义。

Individual variation of minimal concentrationof ftorafur in serum during plateau state w?? ob-served when UFT [ftorafur and uracil (1:4)] 50,40 and 31mg/kg was administered intragastricallyonce a day for eight days in 125 mice with carcino-ma pullulans of HepA. The antitumour effects ofUFT and the weight growing rate (WGR) of micein the third, sixth and eighth days of the experimentshowed marked negative correlations with serumlevel of ftorafur. The necessity and clinical signifi-cance monitoring ftorafur level in serum were dis-cussed.