摘要
代谢作为生物信息流的最下游,承载信息传递的特殊功能,结合上游的基因、转录、蛋白质及神经系统,能够更好地反映大脑的工作原理以及患病机制,揭开大脑的神秘面纱。目前已有许多关于大脑的代谢组学研究,同时结合脑部相关疾病,研究疾病对脑代谢的影响。本文结合精准医学,主要综述代谢组学技术在脑部疾病的精准应用。
As the most downstream of biology information current, metabolism has the special function of information delivery. Work principle and disease mechanism of brain can be better reflected based on the combination of metabolism and gene, transcription, protein and nervous system. At present, there are many reports regarding metabolomics research in the brain to explore the diseases’ effect on brain metabolism. Combined with precision medicine, precision application of metabolomics technology in brain diseases was reviewed in this paper.
出处
《世界科学技术-中医药现代化》
CSCD
2017年第9期1549-1554,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金面上项目(NO.81373519):基于整体代谢网络的异病同证(三焦)湿热证的证候基础及病变机制研究
负责人:张永煜
上海市学位委员会【(2012)13号】:研究生交叉学科创新人才培养平台建设项目
负责人:张永煜
上海市科学技术委员会科研计划项目(13401900306):黄芩总黄酮苷元有效组分抗肾纤维化的成药性研究
负责人:张永煜
关键词
代谢组学
脑部疾病
精准医学
生物信息流
Metabolomics
brain diseases
precision medicine
biology information current
