摘要
精准医疗的本质是对大样本人群及特定疾病类型进行生物标志物的筛选、定量、验证及应用,最终达到寻找疾病的发病原因、机制及治疗靶点的目标。代谢组学作为检测体内代谢物技术之一,可以通过发现体内代谢物水平的变化及时对机体生理状态做出预判与诊断,并指导进行相应的干预及治疗。本文将对代谢组学技术,在心血管疾病精准诊断、发病机制和治疗方面的应用进行综述。
The essence of precision medicine（PM） is to find the disease pathogenesis, mechanism and treatment targets through large sample population and specific disease type of biomarker exploring, quantitative analysis, verifying and application. Metabolomics, as one of the technologies testing the metabolites in vivo, can be used to predict the level of metabolites in vivo and to diagnose the physiological state of the body in time for guiding the corresponding intervention.This article summarized the application of metabonomics in the precise diagnosis, pathogenesis and treatment of cardiovascular disease.
出处
《世界科学技术-中医药现代化》
CSCD
2017年第9期1555-1559,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金面上项目(81373519):基于整体代谢网络的异病同证(三焦)湿热证的证候基础及病变机制研究,负责人:张永煜
上海市学位委员会【(2012)13号】:研究生交叉学科创新人才培养平台建设项目,负责人:张永煜
关键词
代谢组学
心血管疾病
精准医学
Metabonomics
cardiovascular disease
precision medicine
