摘要
目的采用SPG膜乳化法制备载牛血清白蛋白的聚乙二醇-聚乳酸聚乙醇酸(PEG-PLGA)微球,研究投药量对微球性质的影响。方法以包封率、载药量及粒径等为指标,评价PEG-PLGA微球的理化性质。采用扫描电镜观察微球的内外形态结构,并考察微球体外释药行为及吸水膨胀性能。结果随着投药量的增加,微球表面及内部孔洞增加,微球释药速率增快。投药量为75 mg时,实际载药量及吸水膨胀有最大值。结论不同投药量所得微球的内外形态在载蛋白PEG-PLGA微球的释放中发挥重要作用。
OBJECTIVE The influence of the theoretical drug loading on the physicochemical properties of the polyethylene glycol-poly lactic acid-co-glycolic acid( PEG-PLGA) microspheres loaded bovine serum albumin( BSA) fabricated by SPG membrane emulsification was investigated. METHODS Encapsulation efficiency,drug loading and particle size were used to evaluate the physicochemical properties of the microspheres. The surface and internal morphology of the microspheres were investigated by scanning electron microscopy. The release behaviors and the swelling of the microspheres were also systematically studied. RESULTS When the theoretical drug loading increased,the number of surface and internal pores increased,resulted in faster drug release. When the dosage was 75 mg,the microspheres showed highest encapsulation efficiency and swelling ratio. CONCLUSION The microspheres prepared with different theoretical drug loading shows different surface and internal morphology,which plays a significant role in in vitro release behaviors.
出处
《今日药学》
CAS
2017年第11期725-728,共4页
Pharmacy Today
基金
广东省医院药学研究基金(2017A18)
关键词
缓释微球
聚乙二醇-聚乳酸聚乙醇酸
蛋白药物
SPG膜乳化法
sustained-release microspheres
polyethylene glycol-poly lactic acid-co-glycolic acid
protein drug
SPG membraneemulsification