肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展

Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis

衬贴于肝血窦的肝窦内皮细胞具有无隔膜的窗孔,并汇聚成肝筛。窗孔相当于可选择超滤系统,有利于调控肝细胞与肝窦血液的物质交换,尤其是在脂质代谢方面,窗孔结构异常是脂质代谢紊乱的重要因素。本文就窗孔的超微结构、开窗机制和调控因素以及与脂肪肝相关联系的进展做一综述。

Liver sinusoidal endothelial cells （LSECs） are gossamer-thin ceils that line the hepatic sinusoid and they are perforated with pores called fenestrations clustered in sieve plates. There is growing evidence that fenestrations may work as a permselective ultrafihration installation which is important for the hepatic to uptake substrates, particularly metabolism of lipoproteins. Abnormal fenestratel structure had been considered as a vital faetor to liver lipid metabolism disorders. This review mainly foeused on the relationship between uhrastructure of the fenestration, the fenestrated mechanism, the regulation factor of fenestration, and hepatic steatosis.