腹膜透析患者降压药物选择与血压达标情况的相关分析

Correlation analysis of the selection of antihypertensive drugs and standardized blood pressure in patients with peritoneal dialysis

目的评价腹膜透析患者降压药物与血压的相关性,以指导临床选择合适的药物。方法选择2013年1月至2015年6月我科规律随访的腹膜透析患者,根据血压是否达标将患者分为2组,采用双变量相关分析的方法评价各种药物与血压的相关性,进一步采用logistic回归方法分析血压的影响因素。结果共有108例患者纳入研究,两组患者的基线人口学资料、临床指标等差异无统计学意义,收缩压、舒张压与钙通道阻断剂(Calcium channel blocker,CCB)呈现出良好的正相关,logistic回归分析显示,α受体阻断剂(Alpha receptor blocker,α-RB)是血压达标的独立保护因素。结论腹膜透析人群联合应用CCB与α-RB更有利于血压达标。

Objective To evaluate the relationship between the selection of antihypertensive drugs and standardized blood pressure in patients with peritoneal dialysis,in order to choose proper medicines. Methods The peritoneal dialysis patients with regular follow-up from January 2013 to June 2015 were chosen. According to the blood pressure,the patients were divided into two groups. The correlation between all kinds of antihypertensive drugs and blood pressure was evaluated by using bivariate correlation analysis. Logistic regression methods was used to analyze the influencing factors of blood pressure. Results Totally 108 peritoneal dialysis patients were enrolled. There was no significant difference between the two groups in demographic data and clinical indicators. The systolic and diastolic blood pressure showed positive correlation with calcium channel blocker（ CCB）; the logistic regression also showed that alpha receptor blocker（ α-RB） was the independent protective factor for achieving standard blood pressure. Conclusion CCB and α-RB are more beneficial to the standardization of blood pressure in peritoneal dialysis patients.