摘要
目的:观察不同剂量安眠贴巴布剂对失眠小鼠自主行为及睡眠的影响。方法:ICR小鼠PCPA造模后,予安眠贴巴布剂高、中、低剂量及空白贴干预7 d,观察失眠小鼠的自主行为、对戊巴比妥钠催眠时间及阈下催眠剂量。结果:高、中剂量安眠贴组能够明显减少失眠ICR小鼠自发活动、缩短戊巴比妥钠催眠时间。结论:安眠贴巴布剂对失眠ICR小鼠有催眠镇静作用,且以高、中剂量效优。
Objective: To investigate the effect of different doses of Anmian paster on the autonomic behavior and sleep with sleep deprived mice. Method: 48 ICR mice were molded by PCPA and divided into four groups, which were low dose group, middle dose group, high dose group and control group, treated by corresponding dose. Observe the autonomic behavior, time of pentobarbital sodium hypnosis and effect of subthreshold hypnotic dose about the insomnia mice. Results: Anmian paster of high, middle dose group can significantly reduce the insomnia ICR mice's spontaneous activities, shortening the time of pentobarbital sodium hypnosis; have the synergistic effect on sleep in mice and pentobarbital sodium. Conclusion: Anmian paster have the hypnotic and sedative effect on insomnia ICR mice. And by the high, middle dose have the better.effect.
出处
《中医药导报》
2017年第22期36-38,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金青年项目(No.81503631)
上海市卫生局三年行动计划(ZY3-JSFC-2-2020)
上海市科委项目(13401900307)
关键词
ICR小鼠
安眠贴
睡眠剥夺
自主行为
ICR mice
Anmian paster
sleep deprived
autonomic behavior