疏肝和胃穴位埋线法干预化疗延迟性呕吐的临床研究

Clinical Study on Chemotherapy-induced Delay Emesis Treated with Catgut Embedding Therapy of Soothing Liver and Regulating Stomach

目的:观察疏肝和胃穴位埋线法干预化疗延迟性呕吐的临床疗效。方法:纳入使用中-高致吐风险化疗方案的恶性肿瘤患者60例,采用数字随机法分为对照组和治疗组,每组30例,对照组予单纯西医止吐方案,治疗组则在对照组西医止吐方案的基础上予疏肝和胃穴位埋线法干预,评价比较两组化疗期间(2~5 d)的平均呕吐次数、总体治疗疗效和不良反应发生情况。结果:治疗组化疗期间(2~5 d)的平均呕吐次数均明显低于对照组,差异均有统计学意义(P<0.05);治疗组完全缓解率和总有效率分别为36.7%、80.0%,明显高于对照组的10.0%和46.7%,差异均有统计学意义(P<0.05);两组在头痛、眩晕、局部皮肤感染方面的发生率比较,差异无统计学意义(P>0.05),但是在腹胀、便秘的发生率方面,治疗组明显低于对照组,差异有统计学意义(P<0.05)。结论:疏肝和胃穴位埋线法干预化疗延迟性呕吐的效果显著,能够有效降低患者呕吐次数,促进胃肠功能康复,减少患者腹胀、便秘不良反应发生率。

Objective： To observe the clinical effect of clinical study on chemotherapy-induced delay emesis treated with catgut embedding therapy of soothing liver and regulating stomach. Methods： The clinical study selected 60 cases with high spit risk chemotherapy patients,who were randomly divided into control group and ob- servation group, each group had 30 cases, control group were treated with western medicine, observation group were treated with catgut embedding therapy of soothing liver and regulating stomach on the basis of western medicine, the mean number of vomiting episodes （2-5 d）, overall treatment response, and adverse events were compared between the two groups. Results： The average number of vomiting （2-5 d） in the observation group was significantly lower than that in the control group, and the difference was statistically significant （P〈0.05）; The complete remission rate and total effective rate in observation group were 36.67%, 80.00% and 10.00% and 50.00% respectively, the difference was statistically significant （P〈0.05）; The incidence of headache, dizziness and local skin infection was not significantly different between the two groups （P〉0.05）, but the difference was not statistically significant （P〉0.05）, but the incidence of abdominal distension and constipation was significantly lower in the observation group than that in the control group, the difference was statistically significant （P〈0.05）. Conclusion： Catgut embedding therapy of soothing liver and regulating stomach has a good effect on inventing the chemotherapy-induced delay emesis, it can effectively reduce the number of patients with vomiting, promotes the recovery of gastrointestinal function, reduce the incidence of abdominal distension and constipation.