聚焦超声对兔耳痤疮的治疗效果研究

Therapeutic effect of focused ultrasound on rabbit ear acnevv

目的探究聚焦超声治疗兔耳痤疮的可行性和有效性。方法将18只雄性兔分为空白对照组、模型对照组和超声辐照组,后两组按Kligman法建立兔耳痤疮模型。建模成功后,超声辐照组予以超声连续辐照,观察皮肤辐照前、辐照后即刻及辐照14d后病理变化情况。结果建模后兔耳毛囊扩张、角化过度、棘层肥厚;模型对照组与空白对照组相比,毛囊面积、皮脂腺直径等指标差异均有统计学意义(P<0.01);超声辐照后即刻可见兔耳皮肤真皮层水肿,大量炎性细胞浸润,未见凝固性坏死;辐照后14d,超声辐照组毛囊口轻度扩张、轻度角化、棘层变薄,与模型对照组相比,毛囊面积、棘层细胞层数等指标明显减小或减少,差异有统计学意义(P<0.01)。结论聚焦超声治疗兔耳痤疮行之有效。

Objective To investigate the feasibility and effectiveness of focused ultrasound on the ache of rabbit ear. Methods Eighteen male rabbits were randomly divided into blank control group, model control group and ultrasound irradiation group. Acne rabbit ear model was established by Kligman＇s method in model control group and ultrasound irradiation group. Then, continuous ultrasonic irradiation was given in ultrasound irradiation group. Pathological changes were observed at the time of before and after ultrasound irradiation and 14 days after ultrasound irradiation. Results After modeling,hair follicle expansion,hyperkeratosis,acupoint hypertrophy were observed in blank control group. Compared with blank control group, the thickness of horn layer,the sebaceous gland diameter and other index in model control group were statistically significant （P〈0.01） ;After irradiation, there were hyperemia and edema in epidermis,angiotelectasis and inflammatory infiltrating,but coagulative necrosis in slice was not observed, 14 days later,hair follicle mild expansion, mild keratosis, spiny thinning were observed in ultrasound irradiation group, when compared with model control group, the thickness of horn layer, sebaceous gland diameter and other index were decreased in ultrasound irradiation group,and the differences were statistically significant（P〈0.01）. Conclusion The ultrasonic focusing treatment on rabbit ear acne is feasible and effective.