HIF-2α及VEGF在结直肠癌组织中的表达及与患者预后的关系

Expression of HIF-2α and VEGF in colorectal cancer and its relationship with prognosis

目的探讨HIF-2α及VEGF在结直肠癌中的表达情况,HIF-2α及VEGF与临床病理间的关系。方法免疫组织化学技术检测67例结直肠癌及癌旁组织中HIF-2α及VEGF蛋白的表达情况。结果在结直肠癌组织中HIF-2α、VEGF的表达明显高于癌旁组织;HIF-2α及VEGF的表达率随着肿瘤临床分期、淋巴结转移逐渐增加;HIF-2α的表达率随着肿瘤体积增大逐渐增加,而VEGF表达率与肿瘤体积大小无相关性;HIF-2α及VEGF表达率与患者的年龄、性别、肿瘤发生部位及肿瘤分化程度等无关。HIF-2α与VEGF表达呈正相关;Kaplan-Meier生存分析发现HIF-2α表达与患者生存有关,即高表达患者预后差。结论HIF-2α参与了结直肠癌生长、浸润及转移过程,这一过程可能与调节VEGF的表达有关。

Objective To study the expression of HIF-2α and VEGF in eolorectal cancer and to investigate the relationship between them and clinicopathologic parameter. Methods Immunohistochemistry staining was conducted to detect the expression of HIF-2α and VEGF protein in 67 samples of colorectal tumor tissues and 67 samples of normal adjacent tissue. Results The expression of HIF-2α and VEGF in eolorectal cancer tissues was significantly higher than that in adjacent tissues. The expression of HIF- 2α and VEGF increased with the clinical stage and lymph node metastasis. The expression of HIF-2α increased with the tumor volume. The expression of HIF-2α and VEGF was not related to the age,sex,tumor location and tumor differentiation of the patients. HIF-2α was positively correlated with VEGF expression. Kaplan-Meier survival analysis showed that HIF-2α expression was associated with survival, that is, the higher expression of HIF-2α the worse of prognosis was obtained. Conclusion HIF-2α is involved in the process of growth,invasion and metastasis of colorectal cancer. This process may he related to the regulation of VEGF expression.