孕早期胎盘体积和血管指数对小于胎龄儿的预测

First-trimester placental volume and vascular indices in the prediction of small-for-gestational-age neonates

目的:评估孕早期胎盘体积和血管指数预测小于胎龄儿(SGA)能力。方法:回顾性对比分析242例11~13周+6在我院就诊且随访至胎儿足月出生的无合并症、胎儿畸形单胎妊娠适于胎龄儿(AGA)与SGA胎盘体积、胎盘体积中位倍数值(MOM)、多普勒血管指数。结果 :孕早期SGA组胎盘体积、胎盘体积MOM显著低于AGA组(AGA 74.32±20.28,SGA 51.57±11.65,P=0.008;AGA 1.00±0.05,SGA 0.93±0.04,P=0.004)。两组血管指数,包括血管化指数(VI),血流指数(FI)和血管化血流指数(VFI)均无显著差异(VI:P=0.602,FI:P=0.561,VFI:P=0.490)。结论:孕早期三维超声测量的胎盘体积可以预测SGA,而三维能量多普勒血管指数对SGA预测作用不大。

Objective： To evaluate the ability of first-trimester placental volume and vascular indices to predict small-for- gestational-age（SGA） birth weight pregnancies. Methods： Retrospective comparative analysis placental volume, multiples of me- dian（MOM）, Doppler vascular index in 242 single pregnancy at 11-13 weeks＋6 without complications, fetal malformations in our hospital between appropriate-for-gestational-age （AGA） and SGA at delivery. Results： The placental volume and MOM in the SGA group were significandy lower than those in the AGA group （AGA 74.32±20.28, SGA 51.57±11.65, P=0.008; AGA 1.00±0.05, SGA 0.93±0.04, P=-0.004）. There were no significant differences in vascular indices, including vascularization index （VI）, blood flow index（Fl） and vascularized blood flow index（VFI）（VI： P=0.602, Fh P=0.561, VFI： P=0.490）. Conclusions： The placenta volume measured by three-dimensional ultrasonography in 11-13 weeks＋6 can predict SGA, while the vascular indices have little effect on SGA.