氨丁三醇对磁性荧光双功能材料Fe_3O_4/Alendronate@CdSe的影响

Influence of Tris on bifunctional fluorescent magnetic Fe_3O_4/Alendronate@CdSe

采用化学共沉淀法制备Fe_3O_4磁性纳米颗粒,选用阿伦磷酸钠(Alendronate)对Fe_3O_4进行修饰,得到分散性良好、粒径均一的Fe_3O_4/Alendronate复合微球,再制备半导体CdSe量子点,以3-巯基丙酸修饰。将Fe_3O_4/Alendronate复合微球与修饰后的Cd Se量子点连接,得到负载型双功能纳米材料Fe_3O_4/Alendronate@Cd Se;同时研究了氨丁三醇(Tris)试剂对该双功能纳米微球性能的影响,得到复合材料Fe_3O_4/Alendronate/Tris@Cd Se。对这两种纳米粒子进行了结构的测定和性能的表征。实验表明,两种复合材料都具备良好的磁性和荧光性能,且Tris修饰后与量子点连接的双功能材料荧光性能更加优越。该Fe_3O_4/Alendronate/Tris@Cd Se复合材料有望广泛应用于药物分离、可视化、靶向治疗等生命科学领域。

Fe3O4 magnetic nanoparticles were prepared by chemical coprecipitation method, and the Fe3O4/Alendronate composite microspheres with good dispersion and uniform particle size were obtained by modified Alendronate on Fe3O4. Semiconductor Cd Se quantum dots were prepared and modified with 3-mercaptopropionic acid.The Fe3O4/Alendronate composite microspheres were connected with the modified Cd Se quantum dots, and the bifunctional Fe3O4/Alendronate@Cd Se was obtained. The Fe3O4/Alendronate composite microspheres were connected with the modified Cd Se quantum dots, and the bifunctional materials of the core-shell structure Fe3O4/Alendronate@Cd Se were obtained. The experimental results show that the two kinds of composites have good magnetic and fluorescent properties. Moreover, the fluorescent properties of the bifunctional materials modified by Tris are superior. The Fe3O4/Alendronate/Tris@Cd Se composites are expected to be widely used in the field of life science,such as drug separation, visualization, targeted therapy and so on.