儿童脓毒症免疫机制的研究进展

Advance in the immune mechanism of sepsis in children

脓毒症是由感染引起的常见临床危重病症综合征之一。虽然近年有关脓毒症的治疗方法和技术取得一定的进步，但是有关儿童脓毒症的感染性疾病的发病率、病死率仍在逐年升高，成为目前世界范围内感染致死的最主要原因之一。脓毒症的发病机制较为复杂，主要涉及感染、炎症、免疫损伤、凝血异常及组织损伤等方面，至今尚未被完全阐明。大量实验表明免疫机制在脓毒症的发生发展中占据至关重要的地位。该文现将儿童脓毒症相关的免疫机制进展进行综述。

Sepsis is one of the common critical clinical syndromes caused by infection. Currently, in worldwide, although a certain progress has been made in medical therapies and techniques, the morbidity and mortality of infectious diseases associated with pediatric sepsis have been increasing over years, leaving sepsis still being one of the most important reasons resulting in death. The pathogenesis of sepsis is complicated, which has not been fully elucidated, including infection, inflammation, immune injury, coagulation abnormalities, tissue damage and so forth. A large number of experiments show that immune mechanism plays an important role in the occurrence and development of sepsis. This article will review the literature on the immune mechanism of sepsis in children.