轻中度痤疮患者面部皮肤生理指标分析研究

An investigation on the physiological indicators of facial skin in patients with mild to moderate acne

目的通过对轻中度痤疮患者与正常人面部各生理指标的测定比较,分析其中的差异,探讨皮肤生理指标的异常与痤疮发生发展的相关性,为今后对痤疮的预防、控制及治疗提供理论基础。方法选取114例受试对象,实验组为痤疮患者57例,对照组为正常健康志愿者57例。运用无创性皮肤生理功能检测仪,测量受试者前额、鼻部和脸颊的角质层含水量、经表皮失水量(TEWL)、皮肤油脂、皮肤表面p H值、皮肤黑色素、皮肤血红素以及皮肤弹性。另外,对受试者的眼角只做弹性测量。统计分析痤疮患者与正常人各部位各项指标的差异。结果实验组前额、脸颊的角质层含水量低于对照组,差异有统计学意义(P<0.05);实验组前额、脸颊的TEWL值高于对照组,差异有统计学意义(P<0.05);实验组前额、鼻部、脸颊的皮肤油脂和血红素含量高于对照组,差异有统计学意义(P<0.05)。另外,实验组前额、鼻部、脸颊的p H值、黑色素含量、弹性值,鼻部的角质层含水量和TEWL值,以及眼角的弹性值与对照组相比,均差异无统计学意义。结论痤疮患者与正常人相比,面部皮肤屏障功能出现损伤,皮脂分泌增多,TEWL和血红素含量升高,角质层含水量降低与痤疮的发生发展存在相关性。

Objective To investigate the relationship between abnormal skin physiological indicators and the development of acne. Methods 114 volunteers were selected in this study,including 57 patients with mild to moderate acne and 57 healthy human controls. Skin cutin layer water content,transepidermal water loss（ TEWL）,skin sebum,skin p H,skin melanin,skin hemoglobin and skin elasticity were detected by non-invasive physiometry instruments in the following areas： forehead,nose and cheek. In addition,the skin elasticity was still detected in the canthus. Then all the indicators of each part were analyzed to know the difference between acne patients and controls. Results The skin cutin layer water content of forehead and cheek in patients was lower than those of controls（P〈0. 05）. TEWL of forehead and cheek in patients was higher than those of controls（P〈0. 05）. A significant increase was also observed in the level of skin sebum secretion and hemoglobin in the forehead,cheek and nose of patients compared with controls（ P〈0. 05）. However,the level of skin p H,skin melanin and skin elasticity of forehead,cheek and nose,the level of skin cutin layer water content and TEWL of nose,the level of skin elasticity of canthus were all of no significant difference between the patients and controls. Conclusion Compared with controls,the skin barrier of patients with acne is damaged. The increase of sebum secretion,TEWL and hemoglobin,and the decrease of skin cutin layer water content are related to the occurrence and development of acne.