血管生成拟态蛋白在脑膜瘤组织的表达意义

Expression and significance of vasculogenic mimicryproteins in meningiomas

探讨血管生成拟态(VM)在脑膜瘤组织中的表达及意义。收集56例脑膜瘤患者术后肿瘤病理标本,同期18例颅内减压术后的脑组织标本为对照,行免疫组织化学SP法染色,检测VM相关蛋白血管上皮钙黏附素(VE-cadherin)、上皮细胞激酶(EphA2)在脑膜瘤的脑膜组织中的表达;Western blot进一步检测两组VE-cadherin、EphA2蛋白表达。结果显示,与正常脑膜组织相比较,VE-cadherin、EphA2在脑膜瘤中表达阳性率显著提高(P<0.01);随着脑膜瘤病理分级的上升,其VE-cadherin、EphA2蛋白的表达逐渐上升。VM形成相关蛋白VE-cadherin、EphA2参与了脑膜瘤的发生与进展。

To investigate the expression and significance of vasculogenic mimicry（ VM） proteins in meningiomas. 56 cases of meningioma surgical pathology specimens,and in the same period,18 cases after decompression of normal arachnoid tissue as normal control group. VM related proteins of vascular epithelial calcium（ VE-cadherin） and epithelial cell kinase（ EphA2） expression in meningioma tissues were detected by immunohistochemical SP staining and Western blot. Results showed that compared with normal control groups,the positive rate of VE-cadherin,EphA2 expression in meningioma increased significantly（ P〈0. 01）. With the increase of pathological grade of meningiomas,the expression of VE-cadherin and EphA2 protein increased gradually. VE-cadherin and EphA2 protein involved in the VM formation,occurrence and progress in meningioma.