摘要
羊膜间充质干细胞是一类来源于羊膜的干细胞。相比较其他来源的干细胞,羊膜间充质干细胞具有低免疫原性和免疫抑制的特点,这使得羊膜间充质干细胞的移植副作用相对较小。羊膜间充质干细胞移植治疗一些炎症相关疾病,取得了较好的效果,相关的临床试验也逐步开展。现针对羊膜间充质干细胞在免疫调节方面的机制虽然有一定的认识,但仍不是很清楚。本文针对现阶段关于羊膜间充质干细胞的免疫调节功能进行讨论,为进一步开展相关方面的研究奠定理论基础。
The amniotic mesenchymal stem cell is a stem cell derived from the amnion. Compared with other sources of stem cells, the amniotic mesenchymal stem cell possesses the characteristics of low immunogenicity and immunosuppression, for which makes the side effect of transplantation of the amniotic mesenchymal stern cell relatively smaller. The efficient effects of the treatment have been shown in some diseases, which are associated with inflammation. Relevant clinical trials were carried out. Although some of the mechanisms of immtmomodulation of amniotic mesenchymal stem cell has been found, but they are not completely clarified. This review outlines the immune regulatory function of the amniotic mesenchymal stem cell, which provides some information for the further studies.
出处
《中华细胞与干细胞杂志（电子版）》
2017年第5期313-316,共4页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
国家自然科学基金(81671193
81701243)
广东省自然科学基金(2014A030310373)
广州市珠江科技新星专项(201710010047)
中国科学院再生生物学重点实验室开放课题资助(KLRB201503)
