临床慢阻肺问卷（CCQ）在COPD患者中的应用

Clinical COPD questionnaire （CCO） in patients with COPD

尽管慢性阻塞性肺疾病主要累及肺脏，临床表现以呼吸困难为主，但其亦可导致全身不良效应，使患者的活动能力受限加剧，生命质量下降，预后变差，因此对慢阻肺患者生命质量的评估具有重要的临床意义。GOLD2013文件在症状评估方面除建议除使用mMRC和CAT外，新增临床慢阻肺问卷（CCQ）对患者进行症状评估。CCQ是专门检测慢阻肺患者临床控制的自填式问卷，相比于mMRC和CAT的广泛应用及大量文献报道，CCQ目前在国内的临床应用相对局限、相关研究较少，因此本文就CCQ的研发、信度、效度和敏感性四个方面行进综述，并发现该问卷简单易行，具有较好的信度和效度，对COPD患者的病情变化具有较高的敏感性，值得在COPD临床应用中大力推广。

The overall impact of chronic obstructive pulmonary disease （COPD） on individuals is multifaceted and it causes impairment not only in lungs but also in other organs, and even in psychological conditions that result in multiple symptomatic effects and poorer quality of life. Therefore, it is critical to e- valuate patients＇quality of life in the clinical practice. Besides modified Medical British Research Council （mMRC） and COPD assessment test （CAT）, the clinical COPD questionnaire （CCQ）, a self-administered questionnaire was also recommended by GOLD2013 to assess patients＇health status. Compared to the wide- spread use of mMRC and CAT, CCQ was paid less attention in our clinical work. This study focused on the development, reliability, validity and responsiveness of the CCQ among subjects with COPD. We found that CCQ was easily understood with good reliability, validity and responsiveness and the use of the CCQ should be promoted as a health status measurement in more countries and regions.