小型猪气道异物取出后肺复张的时相分析

Time analysis of pulmonary reexpansion after the acute foreign body airway obstruction removal in miniature pigs

目的探讨急性气道异物取出后肺自然复张过程中影像学转归时间窗。方法采用22只中国实验用小型猪，在气管镜下置入封堵支架的方法制作气道异物致急性肺不张的动物模型。在确认肺不张形成后取出支架，连续3周观察肺自然复张的CT影像学表现和组织病理学变化。结果置入气道封堵支架在1周内即可导致肺不张影像学和病理学改变，取出封堵支架后肺不张组织面积每周逐渐减少，但自然恢复至不完全充气状态至少需要3周时间（P〈0．05）。结论1周内气道金属异物所致的急性肺不张，在取出异物后肺自然复张转归时间往往不少于3周。

Objective To investigate the time of spontaneous recovery of atelectasis after removing the acute airway foreign bodies in miniature pigs. Methods Twenty-two miniature pigs were inserted into the occlusion stent in the right lower lobe bronchus by using bronchoscopy. After confirming the formation of atelectasis, the occlusion stent was removed and the imaging changes were observed for 3 weeks continuously. Results Atelectasis was formed within 1 week after the airway occlusion stent implantation in miniature pigs. Pulmonary reexpansion was observed obviously on week 3 ＂after removal of airway occlusion stent （ P 〈 0. 05 ）. Conclusions The spontaneous recovery time of atelectasis, which caused by an acute foreign body airway obstruction within 1 week, may take 3 weeks at least.